Whole blood impedance aggregometry as a biomarker for the diagnosis and prognosis of severe sepsis

Table 5 ROC-curve statistics for impedance aggregometry, sepsis markers, ICU-scores and coagulation variables for the prognosis of severe sepsis

Prognosis of sepsis Test	AUC	Confidence interval	Significance level
Aggregometry
ADP	0.700	0.582 - 0.818	0.008
AA	0.626	0.488 - 0.764	0.093
Col	0.734	0.607 - 0.862	0.002
TRAP	0.756	0.641 - 0.871	0.001
Sepsis Marker
PCT	0.617	0.254 - 0.511	0.117
IL6	0.731	0.126 - 0.413	0.002
CRP	0.504	0.353 - 0.639	0.956
ICU scores
SAPSII	0.605	0.267 - 0.522	0.160
SOFA	0.732	0.154 - 0.382	0.002
Coagulation variables
INR	0.719	0.569 - 0.868	0.006
Thrombin time	0.505	0.347 - 0.662	0.955
Fibrinogen	0.613	0.224 to 0.549	0.159
platelets	0.752	0.135 to 0.361	0.001

Area under curve, asymptotic confidence interval as well as asymptotic P-values are given for impedance aggregometry using the activators adenosine diphosphate (ADP), arachidonic acid (AA), collagen (Col) and thrombin receptor activating peptide (TRAP), as well as for the classical biomarkers procalcitonin (PCT), interleukin 6 (IL-6) and C-reactive protein (CRP), the SAPSII- and SOFA-score and coagulation variables.

ISSN: 1364-8535