Whole blood impedance aggregometry as a biomarker for the diagnosis and prognosis of severe sepsis

Table 3 ROC-curve statistics for impedance aggregometry, sepsis markers, ICU-scores and coagulation variables in postoperative and septic patients

Diagnosis of sepsis Test	AUC	Confidence interval	Significance level
Aggregometry
ADP	0.759	0.677 - 0.842	<0.001
AA	0.669	0.577 - 0.761	0.001
Col	0.808	0.731 - 0.884	<0.001
TRAP	0.700	0.661 - 0.778	<0.001
Sepsis marker
PCT	0.754	0.674 - 0.840	<0.001
IL6	0.604	0.296 - 0.497	0.055
CRP	0.513	0.412 - 0.614	0.813
ICU-scores
SAPS	0.915	0.866 - 0.963	<0.001
SOFA	0.926	0.880 to 0.971	0.001
Coagulation variables
INR	0.617	0.518 - 0.715	0.029
Thrombin time	0.593	0.456 - 0.669	0.285
Fibrinogen	0.563	0.456 - 0.667	0.285
Platelets	0.736	0.649 - 0.823	<0.001

Area under curve, asymptotic confidence interval as well as asymptotic P-values are given for impedance aggregometry using the activators adenosine diphosphate (ADP), arachidonic acid (AA), collagen (Col) and thrombin receptor activating peptide (TRAP), as well as for the conventional sepsis markers procalcitonin (PCT), interleukin 6 (IL 6) and C-reactive protein (CRP).

ISSN: 1364-8535