From: Optimal glycemic control in neurocritical care patients: a systematic review and meta-analysis
Author, year | Patients, number | Diagnosis | Intensive definition | Conventional definition | Duration of protocol | Definition of hypoglycemia | Definition of poor outcome | Timing of nutrition |
---|---|---|---|---|---|---|---|---|
Staszewski, 2011 | 50 | IS | 81-126 mg/dl (iv insulin) | < 180 mg/dl (sc insulin) | 24 hours | < 60 mg/dl | mRS 3-6 (30 days) | Deferred 24 hours |
Green, 2010 | 81 | Mixed | 80-110 mg/dl (iv insulin) | < 150 mg/dl (sc insulin) | ICU stay | < 60 mg/dl | mRS 3-6 (3 months) | EN within 24 hours |
Coester, 2010 | 88 | TBI | 80-110 mg/dl | < 180 mg/dl | ICU stay | < 80 mg/dl | GOS 1-3 (6 months) | EN within 24-48 hours |
Johnston, 2009 | 74 | IS | 70-110 mg/dl | < 200 mg/dl (loose) < 300 mg/dl (usual) | 5 days | < 55 mg/dl | mRS 2-6 (3 months) | PO or EN ASAP |
Azevedo, 2009 | 34 | IS | < 140 mg/dl (IV insulin) | < 150 mg/dl (SC insulin) | NR | NR | eGOS (Hospital dc) | Not specified; carbohydrate restriction in controls |
Meng, 2009 | 240 | TBI | 80-110 mg/dl | 180-200 mg/dl | ICU stay | < 40 mg/dl | GOS 1-3 (6 months) | IV glucose for 24 hours then EN or PN |
Yang, 2009 | 110 | ICH, IS, SAH | 80-150 mg/dl (IV insulin) | Treated with twice daily insulin 30/70 | ICU stay | < 80 mg/dl | mRS 4-6 (time frame unclear) | Not specified |
Bilotta, 2008 | 97 | TBI | 80-120 mg/dl | < 220 mg/dl | ICU stay | < 80 mg/dl | GOS 1-3 (6 months) | EN or PN ASAP |
Kreisel, 2008 | 40 | IS | 80-110 mg/dl | < 200 mg/dl | 5 days | < 60 mg/dl | RS > 2 | Not specified |
Arabi, 2008 | 94 | TBI | 80-110 mg/dl | 180-200 mg/dl | ICU stay | < 40 mg/dl | NR | EN ASAP |
Bruno, 2008 | 46 | IS | 90-130 mg/dl | < 200 mg/dl | 72 hours | < 60 mg/dl | mRS 3-6 (3 months) | Not specified |
Oksanen, 2007 | 90 | AI | 80-110 mg/dl | 110-144 mg/dl | 48 hours | < 55 mg/dl | NR | Not specified |
Azevedo, 2007 | 48 | Mixed | 80-120 mg/dl | < 180 mg/dl | ICU stay | < 40 mg/dl | eGOS (3 months) | IV glucose for 48 hours then EN; carbohydrate restriction in controls |
Bilotta, 2007 | 78 | SAH | 80-120 mg/dl | < 220 mg/dl | ICU stay | < 80 mg/dl | mRS 4-6 (6 months) | EN or PN ASAP |
Walters, 2006 | 25 | IS | 90-144 mg/dl | < 270 mg/dl | 48 hours | NR | NR | Deferred 48 hours |
Van den Berghe, 2005 | 63 | Mixed | 80-110 mg/dl | < 200 mg/dl | ICU stay | < 40 mg/dl | Karnofsky > 60 (12 months) | IV glucose for 24 hours then EN or PN |