Skip to main content

Table 1 Characteristics of studies comparing intensive and conventional glycemic control in neurocritical care patients

From: Optimal glycemic control in neurocritical care patients: a systematic review and meta-analysis

Author, year Patients, number Diagnosis Intensive definition Conventional
definition
Duration of protocol Definition of hypoglycemia Definition of poor outcome Timing of nutrition
Staszewski, 2011 50 IS 81-126 mg/dl (iv insulin) < 180 mg/dl (sc insulin) 24 hours < 60 mg/dl mRS 3-6
(30 days)
Deferred 24 hours
Green, 2010 81 Mixed 80-110 mg/dl (iv insulin) < 150 mg/dl (sc insulin) ICU stay < 60 mg/dl mRS 3-6
(3 months)
EN within 24 hours
Coester, 2010 88 TBI 80-110 mg/dl < 180 mg/dl ICU stay < 80 mg/dl GOS 1-3
(6 months)
EN within 24-48 hours
Johnston, 2009 74 IS 70-110 mg/dl < 200 mg/dl (loose) < 300 mg/dl (usual) 5 days < 55 mg/dl mRS 2-6
(3 months)
PO or EN ASAP
Azevedo, 2009 34 IS < 140 mg/dl (IV insulin) < 150 mg/dl (SC insulin) NR NR eGOS
(Hospital dc)
Not specified; carbohydrate restriction in controls
Meng, 2009 240 TBI 80-110 mg/dl 180-200 mg/dl ICU stay < 40 mg/dl GOS 1-3
(6 months)
IV glucose for 24 hours then EN or PN
Yang, 2009 110 ICH, IS, SAH 80-150 mg/dl (IV insulin) Treated with twice daily insulin 30/70 ICU stay < 80 mg/dl mRS 4-6
(time frame unclear)
Not specified
Bilotta, 2008 97 TBI 80-120 mg/dl < 220 mg/dl ICU stay < 80 mg/dl GOS 1-3
(6 months)
EN or PN ASAP
Kreisel, 2008 40 IS 80-110 mg/dl < 200 mg/dl 5 days < 60 mg/dl RS > 2 Not specified
Arabi, 2008 94 TBI 80-110 mg/dl 180-200 mg/dl ICU stay < 40 mg/dl NR EN ASAP
Bruno, 2008 46 IS 90-130 mg/dl < 200 mg/dl 72 hours < 60 mg/dl mRS 3-6
(3 months)
Not specified
Oksanen, 2007 90 AI 80-110 mg/dl 110-144 mg/dl 48 hours < 55 mg/dl NR Not specified
Azevedo, 2007 48 Mixed 80-120 mg/dl < 180 mg/dl ICU stay < 40 mg/dl eGOS
(3 months)
IV glucose for 48 hours then EN; carbohydrate restriction in controls
Bilotta, 2007 78 SAH 80-120 mg/dl < 220 mg/dl ICU stay < 80 mg/dl mRS 4-6
(6 months)
EN or PN ASAP
Walters, 2006 25 IS 90-144 mg/dl < 270 mg/dl 48 hours NR NR Deferred 48 hours
Van den Berghe, 2005 63 Mixed 80-110 mg/dl < 200 mg/dl ICU stay < 40 mg/dl Karnofsky > 60
(12 months)
IV glucose for 24 hours then EN or PN
  1. AI, anoxic brain injury; ASAP, as soon as possible; eGOS, extended GOS; EN, enteral nutrition; GCS, Glasgow Coma Scale; GOS, Glasgow Outcome Scale; ICH, intracerebral hemorrhage; IS, ischemic stroke; mRS, modified Ranking Scale; NR, not reported; PN, parenteral nutrition; RS, Rankin score; SAH, subarachnoid hemorrhage; TBI, traumatic brain injury.