Figure 1
From: Pattern recognition receptors as key players in adrenal gland dysfunction during sepsis
Cytokine concentrations of IL-1β, IL-6 and TNFα in plasma and adrenal lysates. From WT and TLR2-/- mice treated with PBS (2 hours), ACTH (100 μg/kg; 1 hour), pLTA (1 mg/kg; 2 hours) or PBS/ACTH and pLTA/ACTH (left) and from WT mice that underwent CLP sham operation (sham), CLP with single (CLP-1P) or double (CLP-2P) puncture (right). Animals that survived after 24-hour CLP are labelled 's' and deceased ones 'ns'. Data are presented as mean ± SEM (n ≥ 6). Statistical significance was determined by one-way ANOVA and Bonferroni's post test (vs. PBS within one group) or t test (WT vs. TLR2-/-). *P < 0.05, **P < 0.01, +P < 0.005, ++P < 0.001, #P < 0.0005, ##P < 0.0001.