Validity |
Primary guides |
   Was assignment of patients to treatments really randomized? |
   Were all patients who entered the study accounted for and |
    attributed at its conclusion? |
Secondary guides |
   Were patients, clinicians, study personnel blinded? |
   Were the groups similar at the start of the trial? |
   Aside from experimental intervention, were the groups treated |
    equally? |
What were the results? |
How large was the treatment effect? |
How precise was the treatment effect? |
Clinical application |
Are the results applicable to my patients? |
What is the net impact of the treatment? |