Potential impact of propofol immediately after motor vehicle accident on later symptoms of posttraumatic stress disorder at 6-month follow up: a retrospective cohort study

Table 2 Multivariate analysis of propofol administration and diagnosis of full or partial posttraumatic stress disorder (PTSD) at 1 and 6 months after a motor vehicle accident

PTSD diagnosis		Logistic regression at 1 month			Logistic regression at 6 months
	Covariates	OR	95% CI	P-value	OR	95% CI	P-value
Full or partial	Propofol	1.31	0.41, 4.23	0.647	6.13	1.57, 23.85	0.009
	Age	0.99	0.97, 1.01	0.397	1.04	1.00, 1.07	0.032
	Female	10.02	4.33, 23.17	< 0.001	5.76	1.97, 16.78	0.001
	ISS	1.10	1.05, 1.15	< 0.001	1.04	0.98, 1.11	0.217
	Midazolam	0.46	0.12, 1.69	0.240	0.40	0.06, 2.73	0.349
	Ketamin	1.91	0.62, 5.94	0.262	1.15	0.20, 6.51	0.878
Full	Propofol	0.90	0.09, 8.98	0.928	14.63	2.07, 103.29	0.007
	Age	1.04	0.99, 1.08	0.128	1.01	0.96, 1.06	0.819
	Female	7.53	1.65, 34.44	0.009	5.16	0.99, 27.04	0.052
	ISS	1.07	0.98, 1.17	0.112	0.94	0.82, 1.07	0.352
	Midazolam	0.42	0.02, 7.61	0.555	0.51	0.02, 12.08	0.673
	Ketamine	0.96	0.07, 14.00	0.974	1.19	0.06, 23.97	0.909

The independent variable was use of propofol within 72 h of a motor vehicle accident (MVA); n = 300 participants analyzed by multivariate logistic regression analysis of age, female sex, and administration of ketamine or midazolam within 72 h of an MVA. OR, odds ratio; ISS, injury severity score.

ISSN: 1364-8535