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Table 1 Measured study drug concentrations in the control jars and the extracorporeal membrane oxygenation circuits at 5 minutes and at 1, 6, 12, and 24 hours

From: Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation

Drug, units of concentration

5 minutes

1 hour

6 hours

12 hours

24 hours

 

C

E

C

E

C

E

C

E

C

E

Fentanyl, ng/mL

          

   Median

27

1

25

0.4

26

0.1

22

0.1

22

0

   Range

26-29

1-1

24-25

0.2-0.5

26-28

0-0.2

20-24

0-0.2

20-24

0-0.1

Morphine, ng/mL

          

   Median

136

7

139

8

137

8

139

8

135

8

   Range

134-140

6-7

132-141

7-9

134-140

8-9

135-143

8-8

134-141

7-9

Midazolam, ng/mL

          

   Median

134

175

131

117

138

59

124

42

128

31

   Range

126-155

144-356

124-137

109-261

127-147

54-124

117-132

41- 96

120-131

30-61

Vancomycin, μg/mL

          

   Median

71

73

70

73

72

71

72

71

69

67

   Range

66-80

67-83

69-76

70-86

67-76

69-74

68-74

68-71

67-70

64-70

Meropenem, μg/mL

          

   Median

18

15

17

14

14

10

11

6

7

3

   Range

17-18

11-16

16-18

10-15

13-15

7-11

11-11

4-8

7-8

2-5

  1. C, control jars; E, extracorporeal membrane oxygenation circuits.
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Critical Care

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