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Figure 1 | Critical Care

Figure 1

From: Reversal of Vitamin K Antagonist (VKA) effect in patients with severe bleeding: a French multicenter observational study (Optiplex) assessing the use of Prothrombin Complex Concentrate (PCC) in current clinical practice

Figure 1

Study flowchart. *Severe bleeding was defined as life-threatening or organ-compromising bleeding, external bleeding uncontrolled with conventional measures, bleeding with hemodynamic instability (systolic blood pressure of less than 90 mm Hg or systolic blood pressure decrease of at least 40 mm Hg or mean blood pressure of less than 65 mm Hg or any signs of shock), or hemorrhage requiring urgent surgery or red cell transfusion. INR, international normalized ratio; PCC, prothrombin complex concentrate; VKA, vitamin K antagonist.

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