Table 1 Considered outcomes and definitions

Mortality

Number of deaths as reported/patients receiving at least one treatment

Infection rate

Number of nosocomial infections/patients receiving at least one treatment dose

Hospital length of stay (LOS)^a

Mean (SD) number of hospital days from hospitalization (or intervention) to discharge

ICU LOS^a

Mean (SD) number of ICU days

Transfused blood units

Standard units

Oxygenation index

Mean (SD) ratio of partial oxygen pressure (PO₂): inspired oxygen fraction (FiO₂)

Serum parameters

Alpha-tocopherol

Mean (SD) serum concentration, µmol/L

Aspartate aminotransferase (AST)

Mean (SD) serum concentration, IU/L

Alanine aminotransferase (ALT)

Mean (SD) serum concentration, IU/L

Bilirubin

Mean (SD) serum concentration, mg/dL

C-reactive protein (CRP)

Mean (SD) serum concentration, mg/dL

Creatinine

Mean (SD) serum concentration, mg/dL

Interleukin (IL)-6 change

Mean (SD) difference in serum IL-6 levels between end and beginning of infusion, pg/mL

Lactate

Mean (SD) serum concentration, mmol/L

Triglycerides

Mean (SD) serum concentration, mg/dL

Urea

Mean serum concentration, mmol/L

Other laboratory parameters

Leukotriene B5 (LTB5)

Ex-vivo production by leukocytes^b,

Leukotriene B4 (LTB4)

LTB5/LTB4 ratio

Ex-vivo production by leukocytes

Eicosapentaenoic acid (EPA)

Content in plasma phospholipids, (% of total concentration)

Docosahexaenoic acid (DHA)

Arachidonic acid (AA)

Prothrombin time, PT (Quick)

Laboratory standard

Partial thromboplastin time (PTT)

Laboratory standard

Platelets

Count, × 10³/µL