Figure 3
From: Metformin overdose causes platelet mitochondrial dysfunction in humans
Platelet mitochondrial function of metformin-intoxicated patients. Ten healthy subjects (white bars) and ten metformin-intoxicated patients (black bars) were studied. The activity of platelet respiratory chain (a) complex I (CI) (P = 0.045; rank sum test), (b) complex II and III (CII+III) (P = 0.571; rank sum test) and (c) complex IV (CIV; t test) (P < 0.001) are expressed relative to that of (d) citrate synthase (CS) (P = 0.307; rank sum test). (e) The proportion between normally polarized and abnormally depolarized mitochondria was assessed in terms of JC-1 fluorescence ratio (FL2/FL1) (healthy subjects, n = 6; metformin-intoxicated, n = 4) (P = 0.051; t test). Data are mean and SD. * P < 0.05 versus healthy subjects;° P = 0.05 versus healthy subjects. SD, standard deviation.