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Figure 2 | Critical Care

Figure 2

From: Metformin overdose causes platelet mitochondrial dysfunction in humans

Figure 2

Effects of pH on human platelet oxygen consumption. Platelets from healthy donors were incubated in plasma with saline (white bar) or metformin diluted in saline (16,600 mg/L; grey bar), lactic acid (to mimic metformin-induced lactic acidosis; dark grey bar) or metformin diluted in saline (16600 mg/L) plus sodium bicarbonate (to correct metabolic acidosis; black bar). After 72 hours, (a) plasma pH (P < 0.001; one-way ANOVA), (b) lactate (P < 0.001; one-way ANOVA) and (c) bicarbonate (P < 0.001; one-way ANOVA) concentrations and (d) platelet oxygen consumption (P < 0.001; ANOVA on ranks) (VO2) were measured. Data are mean and SD, from four experiments. * P < 0.05 versus saline (Holm-Sidak method). ANOVA, analysis of variance; SD, standard deviation.

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