Does a reduced glucose intake prevent hyperglycemia in children early after cardiac surgery? a randomized controlled crossover study

Table 3 Glucose, leucine, and albumin kinetics in children receiving low or standard glucose intake after cardiac surgery

	Low glucose intake (2.5 mg/kg per minute)	Standard glucose intake (5.0 mg/kg per minute)	Pvalue
Glucose kinetics (n = 9)^a
Glucose Ra, mg/kg per minute	5.6 ± 0.9	6.6 ± 1.1	0.071
Fractional gluconeogenesis as percentage of Ra	34 ± 3	24 ± 5	0.002
Glucose clearance rate, mL/kg per minute	4.19 ± 0.54	4.03 ± 0.64	0.362
Leucine kinetics, μmol/kg per hour (n = 8)
Leucine Ra	195.2 ± 21.2	209.3 ± 27.3	0.218
Leucine oxidation	63.1 ± 14.6	68.0 ± 15.4	0.573
Leucine release from protein^a	187.0 ± 20.9	201.1 ± 27.3	0.218
Non-oxidative leucine disposal^b	132.1 ± 17.7	141.3 ± 35.5	0.496
Leucine balance	-54.8 ± 14.6	-59.8 ± 15.8	0.573
Albumin synthesis (n = 8)
Fractional albumin synthesis rate, percentage per day	9.2 ± 3.5	9.6 ± 4.0	0.756
Absolute albumin synthesis rate, mg/kg per day	157.3 (94.6)	139.5 (111.3)	0.742
Contribution to total protein synthesis, percentage	4.2 ± 1.3	4.2 ± 1.6	0.976

Normally distributed data (as assessed by Shapiro-Wilk normality test) are presented as mean ± standard deviation, and comparison between glucose intakes - low glucose intake and standard glucose intake - was done by paired samples t test. Non-normally distributed data are presented as median (interquartile range), and comparison between glucose intakes was done by Wilcoxon matched pairs test. ^aIndicative of protein breakdown; ^bindicative of protein synthesis. Ra, rate of appearance.

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