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Table 1 Demographics and clinical characteristics of the derivation cohort

From: The pediatric sepsis biomarker risk model

 

All

Survivors

Non-survivors

Number of subjects

220

197

23

Median age in years (25%, 75%) 1

2.2 (0.8, 5.9)

2.3 (1.0, 5.9)

1.4 (0.2, 4.2)

Median PRISM score (25%, 75%)

15 (8, 22)

13 (7, 20)

28 (20, 37)2

Number of males (%)

137 (62)

120 (61)

17 (74)

Number of females (%)

83 (38)

77 (39)

6 (26)

Number for race (%)

Caucasian

African American

Other 3

Unreported

153 (70)

39 (18)

12 (5)

16 (7)

138 (70)

35 (17)

11 (6)

13 (7)

15 (65)

4 (17)

1 (4)

3 (13)

Number with gram (+) bacteria (%)

70 (32)

61 (31)

9 (39)

Number with gram (-) bacteria (%)

55 (25)

51 (26)

4 (17)

Number with viral infection (%)

16 (7)

13 (7)

3 (13)

Number with fungal infection (%)

7 (3)

6 (3)

1 (4)

Number with no organism isolated (%)

72 (33)

66 (34)

6 (26)

Number with any co-morbidity (%)

91 (41)

82 (42)

9 (39)4

Number with meningitis (%)

12 (5)

10 (5)

2 (9)

Number with cancer (%)

17 (5)

17 (9)

0 (0)

Number with immune suppression (%) 5

16 (7)

13 (7)

3 (13)

  1. 1Two subjects in the derivation cohort were older than stated in the protocol (13 and 14 years of age) but were included in the analysis. 2P < 0.001 vs. survivors. 3Includes Asian, multi-racial, native Hawaiian/Pacific Islander, and American Indian. 4Co-morbidities in non-survivors included anti-phospholipid antibody syndrome; aplastic anemia; chronic lung disease (2 subjects); DiGeorge Syndrome; developmental delay (2 subjects); hypoplastic left heart syndrome; and short gut syndrome. 5Refers to patients with immune suppression not related to cancer (for example, those receiving immune suppressive medication for solid organ transplantation, or those with a primary immune deficiency).
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