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Figure 2 | Critical Care

Figure 2

From: The pediatric sepsis biomarker risk model

Figure 2

Classification tree from the updated model based on the combined derivation and test cohorts (n = 355). The classification tree consists of six biomarker-based decision rules, one age-based decision rule, and fourteen daughter nodes. The classification tree includes five of the twelve candidate stratification biomarkers: C-C chemokine ligand 3 (CCL3), heat shock protein 70 kDa 1B (HSPA1B), interleukin-8 (IL8), granzyme B (GZMB), and matrix metalloproteinase-8 (MMP8). Each node provides the total number of subjects in the node, the biomarker serum concentration- or age-based decision rule, and the number of survivors and non-survivors with the respective rates. For consistency, the serum concentrations of all stratification biomarkers are provided in pg/ml. Terminal nodes 7, 11, and 14 are considered low-risk nodes, whereas terminal nodes 4, 8, 10, 12, and 13 are considered high-risk terminal nodes. To calculate the diagnostic test characteristics, all subjects in the low risk terminal nodes (n = 236) were classified as predicted survivors, whereas all subjects in the high risk terminal nodes (n = 119) were classified as predicted non-survivors. The area under the curve (AUC) for the re-calibrated decision tree was 0.883.

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