Figure 3
From: Therapeutic efficacy of CXCR3 blockade in an experimental model of severe sepsis
Effect of anti-CXCR3 IgG treatment on bacterial burden. Mice were treated with anti-CXC chemokine receptor 3 (anti-CXCR3) IgG (100 μg) or nonspecific IgG (100 μg) 24 hours prior to, 2 hours after or 6 hours after cecal ligation and puncture (CLP). Blood and peritoneal lavage fluid were collected 18 hours after CLP and bacterial colony-forming units (CFU) were measured. Mice designated as control represent septic mice that did not receive antibiotic treatment. n = 10 to 13 mice per group. *P <0.05 compared with nonspecific IgG, +P <0.05 compared with control.