Figure 2
From: Therapeutic efficacy of CXCR3 blockade in an experimental model of severe sepsis
Effect of anti-CXCR3 IgG treatment on core temperature. Mice were treated with anti-CXC chemokine receptor 3 (anti-CXCR3) IgG (100 μg) or nonspecific IgG (100 μg) 24 hours prior to (n = 10 mice per group), 2 hours after (n = 10 mice per group) or 6 hours after (n = 13 mice per group) cecal ligation and puncture (CLP). Rectal temperature was measured 18 hours after CLP. Mice designated as control represent nonseptic mice. *P <0.05 compared with nonspecific IgG, +P <0.05 compared with control.