Doppler resistive index to reflect regulation of renal vascular tone during sepsis and acute kidney injury

Table 3 Characteristics of patients according to mean arterial pressure

	<70 mm Hg	70 to 85 mm Hg	>85 mm Hg	P value
No acute kidney injury	(n = 13)	(n = 19)	(n = 10)
Mean arterial pressure, mm Hg	63 (59-66)^a,b	79 (74-81)^b,c	93 (89-100)^a,c	<0.001
Heart rate, beats per minute	88 (77-92)^a	98 (90-115)^b,c	90 (64-96)^a	0.026
Fluid balance on inclusion day, mL	1,400 (865-2,735)	1,680 (990-2,560)	1,237 (699-2,376)	0.7
Norepinephrine infusion, number (percentage)	6 (46)	9 (47)	3 (30)	0.6
Norepinephrine dose, μg/kg per minute	0.20 (0.06-0.38)	0.19 (0.05-0.36)	0.17 (0.06-0.47)	0.9
Cardiac index, L/minute per m²	2.6 (1.7-3.0)	4.1 (3.1-7.8)	2.7 (1.9-5.0)	0.1
PaO₂/FiO₂ ratio	280 (116-310)	240 (107-302)	229 (193-395)	0.4
Resistance index	0.74 (0.70-0.78)	0.72 (0.68-0.77)	0.69 (0.67-0.72)^c	0.04
Acute kidney injury	(n = 25)	(n = 14)	(n = 13)
Mean arterial pressure, mm Hg	65 (62-66)^a,b	73 (70-76)^b,c	94 (89-104)^a,c	<0.001
Heart rate, beats per minute	95 (83-124)	90 (82-117)	89 (79-112)	0.7
Fluid balance on inclusion day, mL	2,605 (1,303-3,767)	2,650 (2,184-3,481)	1,480 (1,105-2,400)	0.1
Norepinephrine infusion, number (percentage)	16 (64)	10 (71)	3 (23)	0.02
Norepinephrine dose, μg/kg per minute	0.20 (0.06-0.38)	0.19 (0.05-0.36)	0.17 (0.06-0.47)	0.9
Cardiac index, L/minute per m²	2.8 (2.4-3.6)	3.0 (1.8-5.2)	3.7 (3.1-5.9)	0.4
PaO₂/FiO₂ ratio	140 (110-270)	252 (180-310)	180 (134-270)	0.06
Resistance index	0.76 (0.73.80)	0.74 (0.66-0.78)	0.78 (0.73-0.82)	0.1

Results are expressed as median (interquartile range). P value refers to between-group comparisons (Kruskal-Wallis one-way analysis of variance with post hoc analysis). ^aP <0.05 compared with mean arterial pressure (MAP) 70-85 mm Hg group. ^bP <0.05 compared with MAP >85 mm Hg group. ^cP <0.05 compared with MAP <70 mm Hg group. PaO₂/FiO₂, arterial partial pressure of oxygen/fraction of inspired oxygen.

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