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Table 1 Unproven principles of management for mechanical ventilation

From: Mechanical ventilation: past lessons and the near future

Unproven experience-based rules regarding ventilation support

• Modify therapy according to patient size, physiological demand, and tolerance

• Reduce ventilation intensity as well as demand

• It is transpulmonary pressure that counts

• It is functional response that is important

• Position is an essential tool ... and a hazard

• Recruiting maneuvers often required to set best positive end-expiratory pressure