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Table 5 Multivariate modeling: change in outcome variable per 10 U/L decrease in alkaline phosphatase (AP) activity*

From: Alkaline phosphatase activity after cardiothoracic surgery in infants and correlation with post-operative support and inflammation: a prospective cohort study

Outcome variable AP POD1 (95% CI) P-Value R 2 AUC (95% CI)
Intubation, % change 6% (1%, 12%) < 0.05 0.47 n/a
Length of hospital stay, % change 5% (2%, 9%) < 0.05 0.35 n/a
Length of ICU stay, % change 4% (-3%, 8%) ns 0.3 n/a
VIS24, unit change 0.7 (0.4, 1.0) < 0.0001 0.70 n/a
VIS48, OR for change 1.4 (1.1, 1.7) < 0.005 n/a 0.93 (0.87, 1.0)
VIS72, OR for change 1.4 (1.2, 1.7) <0.005 n/a 0.89 (0.81, 0.97)
Poor outcome, OR for change 1.3 (1, 1.8) 0.061 n/a 0.78 (0.66, 0.90)
PCT, POD1, % change 14% (4%, 25%) < 0.01 0.26 n/a
CRP, POD1, %change -4% (-17%, 27%) ns 0.30 n/a
  1. *change expressed as unit change for normally distributed variables, % change for log transformed variables, and odds ratio (OR) change for data with excessive zero values (logistic regression). ICU, Intensive care unit; VIS, vasoactive-inotropic score; POD, post-operative day; PCT, procalcitonin; CRP, C-reactive protein; AUC, area under the curve; CI, confidence interval; ns, not significant; n/a, not applicable.