Alkaline phosphatase activity after cardiothoracic surgery in infants and correlation with post-operative support and inflammation: a prospective cohort study

Table 5 Multivariate modeling: change in outcome variable per 10 U/L decrease in alkaline phosphatase (AP) activity*

Outcome variable	AP POD1 (95% CI)	P-Value	R ²	AUC (95% CI)
Intubation, % change	6% (1%, 12%)	< 0.05	0.47	n/a
Length of hospital stay, % change	5% (2%, 9%)	< 0.05	0.35	n/a
Length of ICU stay, % change	4% (-3%, 8%)	ns	0.3	n/a
VIS24, unit change	0.7 (0.4, 1.0)	< 0.0001	0.70	n/a
VIS48, OR for change	1.4 (1.1, 1.7)	< 0.005	n/a	0.93 (0.87, 1.0)
VIS72, OR for change	1.4 (1.2, 1.7)	<0.005	n/a	0.89 (0.81, 0.97)
Poor outcome, OR for change	1.3 (1, 1.8)	0.061	n/a	0.78 (0.66, 0.90)
PCT, POD1, % change	14% (4%, 25%)	< 0.01	0.26	n/a
CRP, POD1, %change	-4% (-17%, 27%)	ns	0.30	n/a

*change expressed as unit change for normally distributed variables, % change for log transformed variables, and odds ratio (OR) change for data with excessive zero values (logistic regression). ICU, Intensive care unit; VIS, vasoactive-inotropic score; POD, post-operative day; PCT, procalcitonin; CRP, C-reactive protein; AUC, area under the curve; CI, confidence interval; ns, not significant; n/a, not applicable.

ISSN: 1364-8535