Table 5 Renal function and metabolism
Total cohort | Control - no bicarbonate | Intervention - bicarbonate | Significance, P-value | |
|---|---|---|---|---|
Number | 584 | 304 (52.1%) | 280 (47.9%) | |
Diuresis and fluid balance | ||||
Postoperative diuresis within 24 h, ml | 2,844 (2,744, 2,944) | 2,723 (2,564, 2,881) | 2,977 (2,861, 3,092) | 0.012 |
Postoperative cristalloid fluid balance, ml | -124 (-225, -22) | -133 (-295, 30) | -114 (-231, 4) | 0.855 |
Postoperative surgical drainage, ml | 927 (887, 968)] | 933 (875, 991) | 921 (865, 978) | 0.782 |
Postoperative colloidals - drainage fluid balance, ml | 549 (480, 618) | 471 (374, 569) | 633 (536, 731) | 0.022 |
Postoperative diuretics, number of patients | ||||
Furosemide | 280 (47.9%) | 142 (46.7%) | 138 (49.3%) | 0.590 |
Torasemide | 462 (79.1%) | 242 (79.6%) | 220 (78.6%) | 0.838 |
HCT | 200 (34.2%) | 102 (33.6%) | 98 (35.0%) | 0.779 |
Other diuretics | 34 (5.8%) | 20 (6.6%) | 14 (5.0%) | 0.524 |
Renal function | ||||
Creatinine baseline, μmol/L | 81 (79, 83) | 81 (78, 84) | 82 (78, 84) | 0.787 |
Creatinine maximum*, μmol/L | 93 (90, 96) | 93 (88, 97) | 93 (89, 97) | 0.785 |
Creatinine at discharge*, μmol/L | 82 (80, 87) | 84 (80, 88) | 80 (80, 87) | 0.153 |
Maximum relative increase in creatinine* | ||||
< 25% | 369 (63.2%) | 204 (67.1%) | 165 (58.9%) | 0.217 |
> 25% | 123 (21.1%) | 57 (18.8%) | 66 (23.6%) | |
> 50% | 56 (9.6%) | 25 (8.2%) | 31 (11.1%) | |
> 100% | 36 (6.2%) | 18 (5.9%) | 18 (6.4%) | |
eGFR baseline, ml/min | 82 (80, 84) | 81 (78, 84) | 83 (80, 87) | 0.434 |
eGFR minimum*, ml/min | 69 (67, 71) | 69 (66, 72) | 70 (66, 73) | 0.744 |
eGFR at discharge*, ml/min (n = 566) | 82 (79, 85) | 81 (77, 86) | 83 (79, 86) | 0.586 |
AKI grading according to creatinine changes (new RRT = grade 3), number patients | ||||
Grade 1 | 85 (14.6%) | 38 (12.5%) | 47 (16.8%) | 0.478 |
Grade 2 | 7 (1.2%) | 3 (1.0%) | 4 (1.4%) | |
Grade 3 | 74 (12.7%) | 39 (12.8%) | 35 (12.5%) | |
AKI grading according to diuresis** (new RRT = grade 3), number patients | ||||
Grade 1 | 14 (2.4%) | 11 (3.6%) | 3 (1.1%) | 0.135 |
Grade 2 | 1 (0.2%) | 0 (0.0%) | 1 (0.4%) | |
Grade 3 | 45 (7.7%) | 21 (6.9%) | 24 (8.6%) | |
AKI grading, total**, number patients | ||||
Grade 1 | 90 (15.4%) | 44 (14.5%) | 46 (16.4%) | 0.753 |
Grade 2 | 8 (1.4%) | 3 (1.0%) | 5 (1.8%) | |
Grade 3 | 75 (12.8%) | 39 (12.8%) | 36 (12.9%) | |
New RRT | ||||
Patients (%) | 45 (7.7%) | 22 (7.2%) | 23 (8.2%) | 0.774 |
Duration of treatment, h | 144 (114, 196) | 153 (110, 196) | 125 (76, 227) | 0.892 |
Intraoperative metabolism | ||||
Blood glucose max, mg/dl | 193 (189, 202) | 189 (184, 193) | 197 (193, 204) | 0.005 |
Blood glucose min, mg/dl | 92 (91, 93) | 91.5 (89, 94) | 92 (91, 94) | 0.181 |
pH max | 7.45 (7.44, 7.45) | 7.45 (7.45, 7.45) | 7.45 (7.44, 7.45) | 0.034 |
pH min | 7.32 (7.32, 7.32) | 7.32 (7.31, 7.32) | 7.32 (7.32, 7.33) | 0.157 |
Lactate max, mmol/L | 1.7 (1.6, 1.8) | 1.6 (1.5, 1.7) | 1.8 (1.6, 1.9) | 0.005 |
Lactate min, mmol/L | 0.6 (0.6, 0.6) | 0.6 (0.6, 0.7) | 0.7 (0.6, 0.7) | 0.594 |
Postoperative metabolism | ||||
Blood glucose max, mg/dl | 169.0 (166.0, 172.0) | 163.5 (161.0, 167.0) | 173.5 (170.12, 177.88) | 0.0015 |
Blood glucose min, mg/dl | 90.09 (88.68,1.51) | 89.70 (87.73, 91.67) | 90.53 (88.48, 92.57) | 0.566 |
pH max | 7.46 (7.46, 7.47] | 7.46 (7.45, 7.46) | 7.47 (7.46, 7.48) | 0.001 |
pH min | 7.32 (7.31, 7.32) | 7.32 (7.31, 7.32) | 7.32 (7.31, 7.33) | 0.165 |
Lactate max, mmol/L | 2.00 (1.90, 2.10) | 1.90 (1.70, 2.00) | 2.10 (2.00, 2.20) | 0.010 |