Total cohort | Control - no bicarbonate | Intervention - bicarbonate | Significance, P-value | |
---|---|---|---|---|
Number of patients | 584 | 304 | 280 | |
HR, bpm, preoperative | 68 (67, 70) | 68.5 (67, 70) | 68 (67, 70) | 0.875 |
MAP, mmHg, preoperative | 96 (95, 98) | 97 (95, 100) | 95 (93, 97) | 0.396 |
MAP, mmHg, before induction | 85 (82, 85) | 87 (85, 90) | 80 (76, 83) | < 0.0001 |
MAP, mmHg, 30 minutes before CPB | 70 (70, 71) | 70 (70, 72) | 70 (68, 71) | 0.135 |
MAP, mmHg, 30 minutes after CPB | 69 (68, 70) | 70 (69, 71) | 69 (67, 70) | 0.109 |
MAP, mmHg, end of surgery | 72 (71, 73) | 73 (71, 74) | 71 (70, 73) | 0.150 |
MAP, mmHg, ICU admission | 76 (75, 77) | 76 (75, 78) | 75 (73, 78) | 0.339 |
MAP, mmHg, 2 h after ICU admission | 73 (72, 74) | 73 (71, 75) | 73 (72, 74) | 0.833 |
MAP, mmHg, 4 h after ICU admission | 74 (72, 75) | 74 (72, 76) | 73 (72, 74) | 0.541 |
MAP, mmHg, 6 h after ICU admission | 73 (73, 74) | 74 (73, 75) | 73 (72, 75) | 0.361 |
MAP, mmHg, 8 h after ICU admission | 74 (73, 75) | 74 (72, 75) | 74 (72, 75) | 0.632 |
CVP, mmHg, after induction | 11 (10, 11) | 11 (10, 11) | 11 (10, 12) | 0.340 |
CVP, mmHg, 30 minutes before CPB | 8 (8, 8) | 8 (8, 9) | 8 (7, 9) | 0.561 |
CVP, mmHg, 30 minutes after CPB | 11 (10, 11) | 10 (10, 11) | 11 (10, 12) | 0.663 |
CVP, mmHg, end of surgery | 12 (11, 12) | 12 (11, 12) | 12 (11, 12) | 0.396 |
CVP, mmHg, ICU admission | 15 (15, 16) | 16 (15, 16) | 15 (15, 16) | 0.689 |
CVP, mmHg, 2 h after ICU admission | 15 (15, 16) | 16 (15, 16) | 15 (14, 15) | 0.129 |
CVP, mmHg, 4 h after ICU admission | 15 (15, 16) | 15 (14, 16) | 15 (15, 16) | 0.425 |
CVP, mmHg, 6 h after ICU admission | 14 (14, 15) | 14 (14, 15) | 14 (14, 15) | 0.358 |
CVP, mmHg, 8 h after ICU admission | 13 (13, 14) | 13 (12, 14) | 13 (12, 14) | 0.801 |
MPAP, mmHg, After induction | 25 (24, 27) | 26 (24, 29) n = 61 | 25 (22, 29) n = 46 | 0.380 |
MPAP, mmHg, 30 minutes after CPB | 25 (23, 27) | 26 (23, 28) n = 76 | 25 (22, 27) n = 75 | 0.466 |
MPAP, mmHg, 30 minutes after CPB | 26 (24, 27) | 25 (23, 28) n = 104 | 26 (24, 28) n = 97 | 0.324 |
MPAP, mmHg, end of surgery | 26 (25, 28) | 26 (24, 28) n = 107 | 27 (24, 29) n = 94 | 0.659 |
MPAP, mmHg, ICU admission | 29 (28, 30) | 30 (29, 33) n = 113 | 27 (26, 29) n = 84 | 0.006 |
MPAP, mmHg, 2 h after ICU admission | 30 (29, 31) | 30 (29, 31) n = 120 | 29 (28, 31) n = 104 | 0.538 |
MPAP, mmHg, 4 h after ICU admission | 30 (29, 31) | 31 (29, 32) n = 126 | 29 (28, 30) n = 107 | 0.448 |
MPAP, mmHg, 6 h after ICU admission | 29 (27, 29) | 29 (27, 30) n = 125 | 28 (27, 30) n = 109 | 0.892 |
MPAP, mmHg, 8 h after ICU admission | 28 (27, 29) | 28 (26, 30) n = 128 | 28 (26, 30) n = 113 | 0.731 |
CI, L/min/m2, after induction | 2.45 (2.24, 2.66) | 2.46 (2.14, 2.77) n = 56 | 2.44 (2.17, 2.71) n = 38 | 0.947 |
CI, L/min/m2, 30 minutes before CPB | 2.68 (2.57, 2.80) | 2.62 (2.45, 2.79) n = 76 | 2.75 (2.58, 2.92) n = 75 | 0.269 |
CI, L/min/m2, 30 minutes after CPB | 3.22 (3.08, 3.37) | 3.14 (2.94, 3.34) n = 104 | 3.31 (3.09, 3.53) n = 97 | 0.261 |
CI, L/min/m2, end of surgery | 3.02 (2.92-3.13) | 2.95 (2.79, 3.11) n = 107 | 3.11 (2.97, 3.25) n = 94 | 0.140 |
CI, L/min/m2, ICU admission | 2.80 (2.69, 2.92) | 2.87 (2.73, 3.01) n = 113 | 2.71 (2.52, 2.89) n = 84 | 0.171 |
CI, L/min/m2, 2 h after ICU admission | 3.06 (2.95, 3.17) | 3.07 (2.92, 3.22) n = 120 | 3.05 (2.88, 3.21) n = 104 | 0.835 |
CI, L/min/m2, 4 h after ICU admission | 3.12 (3.02, 3.23) | 3.10 (2.98, 3.23) n = 126 | 3.15 (2.98, 3.32) n = 107 | 0.675 |
CI, L/min/m2, 6 h after ICU admission | 3.24 (3.14, -3.35) | 3.22 (3.10, 3.34) n = 125 | 3.27 (3.08, 3.46) n = 109 | 0.686 |
CI, L/min/m2, 8 h after ICU admission | 3.18 (3.09, 3.28) | 3.23 (3.11, 3.35) n = 128 | 3.13 (2.98, 3.28) n = 113 | 0.301 |
SvO 2 , %, after induction (n = 118) | 79 (77, 80) | 79 (78, 81) n = 61 | 77 (75, 79) n = 46 | 0.060 |
SvO 2 , %, 30 minutes before CPB (n = 147) | 82 (81, 82) | 82 (81, 83) n = 76 | 81 (80, 82) n = 75 | 0.357 |
SvO 2 , %, 30 minutes after CPB (n = 177) | 78 (77, 79) | 79 (77, 80) n = 104 | 78 (77, 80) n = 97 | 0.735 |
SvO 2 , %, end of surgery (n = 179) | 77 (76, 78) | 77 (76, 79) n = 107 | 77 (76, 79) n = 94 | 0.988 |
SvO 2 , %, ICU admission (n = 192) | 71 (70, 72) | 71 (70, 73) n = 113 | 70 (68, 72) n = 84 | 0.380 |
SvO 2 , %, 2 h after ICU admission (n = 287) | 69 (68, 70) | 69 (67, 70) n = 120 | 69 (67, 70) n = 104 | 0.931 |
SvO 2 , % 4 h after ICU admission (n = 309) | 68 (67, 69) | 67 (66, 69) n = 126 | 68 (67, 69) n = 107 | 0.322 |
SvO 2 , %, 6 h after ICU admission (n = 316) | 69 (68, 70) | 69 (68, 70) n = 125 | 69 (67, 70) n = 109 | 0.587 |
SvO 2 , %, 8 h after ICU admission | 69 (68, 70) | 69 (68, 71) n = 128 | 69 (67, 70) n = 113 | 0.264 |