Table 1 Demographic data and preoperative risk stratification
Total cohort | Control - no bicarbonate | Intervention - bicarbonate | Significance, P-value | |
|---|---|---|---|---|
Number | 584 | 304 (52.1%) | 280 (47.9%) | |
Demographics | ||||
Age, years | 68.5 (67, 69) | 68.5 (67, 70) | 68.5 (67, 70) | 0.675 |
Male | 381 (65.2%) | 201 (66.1%) | 180 (64.3%) | 0.706 |
Female | 203 (34.8%) | 103 (33.9%) | 100 (35.7%) | |
Height, cm | 171 (170, 172) | 171 (170, 173) | 171 (170, 172) | 0.741 |
Weight, Kg | 81.3 (79.9, 82.6) | 82.3 (80.6, 84.1) | 80.1 (78.1, 82.1) | 0.103 |
BMI (Kg/m2) | 27.2 (26.8, 27.7) | 27.4 (26.8, 27.9) | 26.9 (26.5, 27.8) | 0.098 |
Cardiovascular risk factors | ||||
Diabetes mellitus | 158 (27.1%) | 72 (23.8%) | 86 (30.7%) | 0.073 |
Arterial hypertension | 484 (82.9%) | 250 (82.2%) | 234 (83.6%) | 0.751 |
Smoking (former or present smoker) | 246 (42.3%) | 125 (41.5%) | 121 (43.2%) | 0.744 |
Hyperlipidemia | 410 (70.2%) | 217 (71.4%) | 193 (68.9%) | 0.578 |
Arterial vascular disease | 135 (23.1%) | 62 (20.4%) | 73 (26.1%) | 0.127 |
PAH (systolic > 60 mmHg) (n = 223) | 32 (14.3%) | 12 (11.1%) | 20 (17.4%) | 0.252 |
PAH (systolic > 40 mmHg) (n = 223) | 112 (50.2%) | 56 (51.9%) | 56 (48.7%) | 0.736 |
NYHA I/II | 348 (59.6%) | 184 (60.5%) | 164 (58.6%) | 0.692 |
NYHA III/IV | 236 (40.4%) | 120 (39.5%) | 116 (41.4%) | |
LVEF < 30% | 32 (5.5%) | 18 (6.0%) | 14 (5.0%) | 0.658 |
LVEF 30 to 50% | 139 (24.0%) | 68 (22.6%) | 71 (25.5%) | |
LVEF > 50% | 408 (70.5%) | 215 (71.4%) | 193 (69.4%) | |
ASA | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 0.801 |
Add. EuroSCORE | 5 (5, 5) | 5 (5, 5) | 4 (5, 5) | 0.455 |
Add. EuroSCORE 0 to 2 | 134 (22.9%) | 63 (20.7%) | 71 (25.4%) | 0.300 |
Add. EuroSCORE 3 to 5 | 205 (35.1%) | 114 (37.5%) | 91 (32.5%) | |
Add. EuroSCORE > 5 | 245 (42.0%) | 127 (41.8%) | 118 (42.1%) | |
Other risk factors | ||||
Pulmonary disease | 91(15.6%) | 46 (15.1%) | 45 (16.1%) | 0.843 |
Neurological disease | 70 (12.0%) | 36 (11.8%) | 34 (12.1%) | 0.988 |
Left main stem disease | 84 (14.4%) | 42 (13.8%) | 42 (15.0%) | 0.772 |
Previous cardiac or thoracic vascular surgery | 63 (10.8%) | 31 (10.2%) | 32 (11.4%) | 0.730 |
History of myocardial infarction | 132 (22.6%) | 80 (26.3%) | 52 (18.6%) | 0.033 |
Troponin-T positive status | 14 (2.4%) | 11 (3.6%) | 3 (1.1%) | 0.082 |
History of cardiogenic shock or acute decompensated heart failure | 71 (12.2%) | 32 (10.6%) | 39 (13.9%) | 0.278 |
Preoperative physiological profile | ||||
MAP, mmHg | 97 (96, 98) | 98 (96, 100) | 96 (93, 99) | 0.305 |
Heart rate, bpm | 68 (67, 70) | 68.5 (67, 70) | 68 (67, 70) | 0.918 |
Mean ScO2room, % | 63 (62, 63) | 62 (62, 64) | 63 (62, 64) | 0.695 |
Mean ScO2ox, % | 68 (67, 68.17) | 68 (67, 69) | 68 (67, 69) | 0.926 |
ScO2minox, % | 66 (65, 67) | 66 (65, 67) | 65 (65, 67) | 0.924 |
NTproBNP, pg/ml (n = 389) | 455 (355, 519) | 392 (312, 496) | 517 (391, 686) | 0.234 |
hsTNT, pg/ml (n = 389) | 9 (8, 11) | 9 (8, 13) | 9 (7, 11) | 0.850 |