Table 2 Summary of stratified analyses of pooled relative risks and standardized mean difference

Disease

   Septic shock

4

989

0.87 (0.75 to 1.00)

0.05

0.76

0.88 (0.62 to 1.25)

0.47

0.61

   Nonseptic shock

2

58

0.95 (0.65 to 1.37)

0.77

0.46

-

-

-

Norepinephrine reduction

Design

   Double-blind

3

813

-1.75 (-1.91 to -1.59)

<0.0001

<0.0001

-

-

-

   Open-label

5

170

-0.45 (-0.85 to -0.06)

0.03

0.70

-1.97 (-2.62 to -1.32)

<0.0001

<0.0001

Disease

   Septic shock

6

925

-1.64 (-1.79 to -1.48)

<0.0001

<0.0001

-1.97 (-2.62 to -1.32)

<0.0001

<0.0001

   Nonseptic shock

2

48

-0.66 (-1.22 to -0.11)

0.02

0.03

-

-

-

Vasopressin dosage

   ≤0.05 U/minute

2

809

-1.66 (-1.83 to -1.50)

<0.0001

0.005

-

-

-

   >0.05 U/minute

4

105

-0.77 (-1.22 to -0.32)

0.0008

<0.0001

-

-

-

Terlipressin dosage

   ≤40 μg/hour

1

39

-

-

-

-4.63 (-5.88 to -3.38)

<0.0001

-

   >40 μg/hour

1

30

-

-

-

-0.98 (-1.74 to -0.22)

0.01

-

Cardiac index

Design

   Double-blind

3

46

0.94 (0.29 to 1.58)

0.004

0.45

-

-

-

   Open-label

6

190

0.03 (-0.36 to 0.42)

0.89

0.80

-0.44 (-0.87 to -0.02)

0.04

0.54

Disease

   Septic shock

7

176

0.44 (-0.00 to 0.88)

0.05

0.10

-0.44 (-0.87 to -0.02)

0.04

0.54

   Nonseptic shock

2

58

0.05 (-0.47 to 0.56)

0.86

0.70

-

-

-

Terlipressin dosage

   ≤40 μg/hour

1

39

-

-

-

-0.29 (-0.92 to 0.35)

0.38

-

   >40 μg/hour

2

50

-

-

-

-0.57 (-1.14 to -0.00)

0.05

0.37

Follow-up

   ≤24 hours

5

103

0.94 (0.29 to 1.58)

0.004

0.45

-0.48 (-1.00 to 0.04)

0.07

0.28

   >24 hours

4

131

0.03 (-0.36 to 0.42)

0.89

0.80

-0.37 (-1.09 to 0.35)

0.31

-

Patients

   ≤25

5

87

0.52 (0.02 to 1.03)

0.04

0.12

-0.91 (-1.84 to 0.02)

0.06

-

   25 to 50

4

147

0.08 (-0.36 to 0.53)

0.72

0.65

-0.32 (-0.80 to 0.15)

0.18

0.86

Oxygen delivery

Terlipressin dosage

   ≤40 μg/hour

1

39

-

-

-

-0.75 (-1.40 to -0.10)

0.02

-

   >40 μg/hour

2

50

-

-

-

-0.83 (-1.42 to -0.25)

0.005

0.38

Oxygen consumption

Terlipressin dosage

   ≤40 μg/hour

1

39

-

-

-

-0.13 (-0.76 to 0.50)

0.69

-

   >40 μg/hour

2

50

-

-

-

-0.52 (-1.08 to 0.05)

0.07

0.64

Gastric PaCO ₂ gap

Vasopressin dosage

   ≤0.05 U/minute

1

30

-0.38 (-1.11 to 0.34)

0.30

-

-

-

-

   >0.05 U/minute

3

95

0.43 (0.01 to 0.84)

0.04

0.09

-

-

-

Terlipressin dosage

   ≤40 μg/hour

1

39

-

-

-

-0.15 (-0.78 to 0.48)

0.64

-

   >40 μg/hour

1

30

-

-

-

-0.94 (-1.70 to -0.18)

0.02

-