Table 3 Characteristics of the 1,914 Greek patients stratified according to four degrees of severity by APACHE II score and serum suPAR
APACHE II score <17 + suPAR <12 ng/mL | APACHE II score <17 + suPAR ≥12 ng/mL | APACHE II score ≥17 + suPAR <12 ng/mL | APACHE II score ≥17 + suPAR ≥12 ng/mL | P value | |
|---|---|---|---|---|---|
Male/female | 480/413 | 162/172 | 170/123 | 216/178 | 0.014 |
Age in years, mean ± SD | 59.4 ± 21.4 | 68.3 ± 18.7 | 73.3 ± 14.9 | 74.2 ± 13.7 | <0.0001 |
Sepsis stage, number (percentage) | <0.0001 | ||||
Sepsis | 747 (83.6) | 232 (67.4) | 113 (38.6) | 95 (24.1) | |
Severe sepsis | 105 (11.8) | 68 (20.3) | 105 (35.8) | 134 (34.0) | |
Septic shock | 41 (4.6) | 43 (12.9) | 75 (25.6) | 164 (41.6) | |
Underlying infections, number (percentage) | <0.0001 | ||||
CAP | 169 (18.9) | 55 (16.5) | 93 (31.7) | 87 (22.1) | |
HAP | 32 (3.6) | 12 (3.6) | 30 (10.2) | 35 (8.9) | |
VAP | 29 (2.3) | 15 (4.5) | 30 (10.2) | 48 (12.2) | |
UTI | 346 (38.7) | 128 (38.3) | 67 (22.9) | 94 (23.9) | |
IAI | 260 (29.1) | 80 (23.9) | 35 (11.9) | 61 (15.5) | |
BSI | 57 (6.4) | 44 (13.2) | 38 (12.9) | 69 (17.5) | |
Underlying conditions, number (percentage) | <0.0001 | ||||
COPD | 78 (8.7) | 33 (9.9) | 45 (15.4) | 54 (13.7) | |
DM2 | 143 (16.1) | 90 (26.9) | 74 (25.3) | 123 (31.2) | |
Heart failure | 104 (11.6) | 49 (14.7) | 62 (21.2) | 98 (24.8) | |
CRD | 35 (3.9) | 29 (8.7) | 27 (9.2) | 85 (21.6) | |
Intake of corticosteroids | 27 (3.0) | 8 (2.3) | 16 (5.5) | 22 (5.6) | |
Malignancy | 42 (4.7) | 18 (5.4) | 17 (5.8) | 30 (7.6) | |
Length of ICU staya in days, median (range) | 19.5 (1-312) | 20.0 (2-317) | 22.5 (1-309) | 14.5 (1-240) | 0.196 |