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Table 2 Parameters and laboratory results during renal replacement therapy (RRT).

From: Sustained low efficiency dialysis using a single-pass batch system in acute kidney injury - a randomized interventional trial: the REnal Replacement Therapy Study in Intensive Care Unit PatiEnts

  All (n = 232) SLED (n = 115) CVVH (n = 117) P*
Norepinephrine (µ/kg/min) 0.128 ± 0.129 0.137 ± 0.149 0.121 ± 0.11 0.266
Epinephrine (µ/kg/min) (n = 30) 0.100 ± 0.359 0.156 ± 0.233 0.243 ± 0.456 0.273
Dobutamine (µ/kg/min) (n = 109) 2.561 ± 1.446 2.710 ± 1.288 2.425 ± 1.576 0.015
Furosemide dose (mg/24h) 298.4 ± 239.5 311.0 ± 259.2 286.1 ± 218.9 0.365
Urine output (ml/24h) 1945 ± 1647 1860 ± 1693 2027 ± 1605 0.121
Duration of treatment (h)
(values after exclusion of incomplete first and last treatment, see Methods)
16.7 ± 4.8 14.9 ± 4.4 15.9 ± 4.2
(19.9 ± 3.64)
0.024
Average number of treatments 7.67 ± 8.39 7.50 ± 8.89 7.83 ± 7.92 0.096
Absolute number of treatments 1694 817 877  
Net ultrafiltration (ml/24h) 1730 ± 1099 1850 ± 1179 1617 ± 1008 0.089
Fluid balance (ml/24h) 636 ± 1405 533 ± 1364 736 ± 1443 0.195
Effective blood flow (ml/min) 113.2 ± 15.5 125.7 ± 9.65 101.7 ± 9.82 < 0.001
Effluent flow (ml/h)    2390 ± 426  
Effluent flow rate (ml/kg/h)    30.87 ± 7.66  
Dialysate flow (ml/h)   120.9 ± 20.3   
Body temperature before RRT (°C) 36.5 ± 0.7 36.6 ± 0.7 36.4 ± 0.6 0.002
Change in body temperature during RRT (°C) -0.2 ± 0.7 -0.3 ± 0.7 - 0.17 ± 0.7 0.011
Heparin (IU/24h) 4874 ± 4004 4554 ± 3594 5191 ± 4438 0.200
Hemoglobin (g/dl) 9.01 ± 0.95 9.06 ± 0.92 8.97 ± 0.97 0.276
Hematocrit (%) 0.29 ± 0.32 0.27 ± 0.03 0.30 ± 0.45 0.237
White blood cell count (/nl) 13.4 ± 7.3 13.0 ± 6.3 13.7 ± 8.2 0.460
Thrombocytes (/nl) 157.8 ± 123.5 157.2 ± 133.5 158.5 ± 113.4 0.177
C-reactive protein (mg/l) 107.5 ± 63.1 110.2 ± 66.8 105.1 ± 59.4 0.392
Albumin (g/l) 23.9 ± 4.6 24.1 ± 4.6 23.7 ± 4.6 0.306
pH 7.38 ± 0.05 7.38 ± 0.06 7.38 ± 0.05 0.242
HCO3- (mmol/l) 23.6 ± 2.55 23.6 ± 2.47 23.6 ± 2.62 0.478
Lactate (mg/dl) 21.1 ± 25.3 19.4 ± 22.9 22.7 ± 27.5 0.260
Serum creatinine pre-treatment (mg/dl) 1.85 ± 0.80 1.77 ± 0.90 1.92 ± 0.68 0.007
Serum creatinine after treatment (mg/dl) 1.46 ± 0.75 1.26 ± 0.80 1.66 ± 0.65 < 0.001
Urea pre-treatment (mg/dl) 113.5 ± 48.3 105.7 ± 55.7 121.2 ± 38.4 0.002
Urea after treatment (mg/dl) 87.1 ± 35.6 68.4 ± 31.2 105.5 ± 29.7 < 0.001
Phosphate pre-treatment (mmol/l) 1.39 ± 1.50 1.42 ± 2.03 1.35 ± 0.52 0.018
Phosphate after treatment (mmol/l) 1.02 ± 0.37 0.88 ± 0.34 1.18 ± 0.35 < 0.001
Calcium (mmol/l) 2.07 ± 0.19 2.04 ± 0.16 2.10 ± 0.22 0.007
Total packed red blood cell Transfusion per patient (ml) 1680 ± 2981 1375 ± 2573 1976 ± 3316 0.019
Total fresh frozen plasma per patient (ml) 1586 ± 4290 1285 ± 3942 1878 ± 4603 0.115
  1. All values are expressed as daily mean (unless otherwise indicated) ± SD; statistical analyses were performed for SLED versus CVVH; *one-tailed Wilcoxon test. SLED: sustained low efficiency dialysis; CVVH: continuous veno-venous hemofiltration.