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Table 2 Results of BALF and serum GM detection and isolation of Aspergillus from LRT in critically ill COPD patients.

From: Role of galactomannan determinations in bronchoalveolar lavage fluid samples from critically ill patients with chronic obstructive pulmonary disease for the diagnosis of invasive pulmonary aspergillosis: a prospective study

  BALF GM ( 95%CI)
(cut-off 0.8)
BALF GM ( 95%CI)
(cut-off 0.5)
Serum GM ( 95%CI)
(cut-off 0.5)
Isolation of Aspergillus from LRT ( 95%CI)
Sensitivity (%) 88.9 (76.8 to 101) 88.9 (76.8 to 101) 77.8 (61.8 to 93.8) 66.7 (48.6 to 84.8)
Specificity (%) 100 (100 to 100) 47.1 (27.9 to 66.3) 100 (100 to 100) 100 (100 to 100)
PPV (%) 100 (100 to 100) 47.1 (27.9 to 66.3) 100 (100 to 100) 100 (100 to 100)
NPV (%) 94.4 (85.6 to 103.2) 88.9 (76.8 to 101) 89.5 (77.7 to 101.3) 85.0 (71.3 to 98.7)
TCR (%) 96.1 (88.7 to 103.5) 61.5 (42.8 to 80.2) 92.3 (82.1 to 102.5) 88.5 (76.2 to 100.8)
  1. For probable IPA and control patients (n = 26).
  2. BALF, bronchoalveolar lavage fluid; COPD, chronic obstructive pulmonary disease; GM, galactomannan; IPA, invasive pulmonary aspergillosis; LRT, lower respiratory tract; NPV, negative predictive value; PPV, positive predictive value; TCR, total consistent rate.