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Table 2 Results of BALF and serum GM detection and isolation of Aspergillus from LRT in critically ill COPD patients.

From: Role of galactomannan determinations in bronchoalveolar lavage fluid samples from critically ill patients with chronic obstructive pulmonary disease for the diagnosis of invasive pulmonary aspergillosis: a prospective study

 

BALF GM ( 95%CI)

(cut-off 0.8)

BALF GM ( 95%CI)

(cut-off 0.5)

Serum GM ( 95%CI)

(cut-off 0.5)

Isolation of Aspergillus from LRT ( 95%CI)

Sensitivity (%)

88.9 (76.8 to 101)

88.9 (76.8 to 101)

77.8 (61.8 to 93.8)

66.7 (48.6 to 84.8)

Specificity (%)

100 (100 to 100)

47.1 (27.9 to 66.3)

100 (100 to 100)

100 (100 to 100)

PPV (%)

100 (100 to 100)

47.1 (27.9 to 66.3)

100 (100 to 100)

100 (100 to 100)

NPV (%)

94.4 (85.6 to 103.2)

88.9 (76.8 to 101)

89.5 (77.7 to 101.3)

85.0 (71.3 to 98.7)

TCR (%)

96.1 (88.7 to 103.5)

61.5 (42.8 to 80.2)

92.3 (82.1 to 102.5)

88.5 (76.2 to 100.8)

  1. For probable IPA and control patients (n = 26).
  2. BALF, bronchoalveolar lavage fluid; COPD, chronic obstructive pulmonary disease; GM, galactomannan; IPA, invasive pulmonary aspergillosis; LRT, lower respiratory tract; NPV, negative predictive value; PPV, positive predictive value; TCR, total consistent rate.