Figure 7From: Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in miceEnhanced neutrophil recruitment into the lung and liver after rhDNase treatment. (A, B) Neutrophil counts in the lung and liver of mice 6 (n = 5), 24 (n = 7), and 48 (n = 7) hours after CLP treated with either 5 mg/kg rhDNase (CLP + rhDNase) or 100 µl PBS (CLP) 1, 4, 7, 10, 21, 24, and 27 hours after CLP. **P < 0.01, ***P < 0.001 versus adjacent time point; #P < 0.05; ###P < 0.001 versus CLP. Chloracetatesterase staining of paraffin sections from the lung and liver of mice 24 hours after CLP treated with either 5 mg/kg rhDNase (CLP + rhDNase) or 100 µl PBS (CLP). Representative sections of the liver (C) and lung (D) are depicted. Scale bar indicated 100 μm. CLP, cecal ligation and puncture; DNase, desoxyribonuclease; NETs, neutrophil extracellular traps; PBS, phosphate-buffered saline; rh, recombinant human.Back to article page