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Figure 6 | Critical Care

Figure 6

From: Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice

Figure 6

Enhanced IL-6 levels without NETs activity. IL-6 levels in the serum of mice 6 (n = 5), 24 (n = 7), and 48 (n = 7) hours after CLP treated with either 5 mg/kg rhDNase (CLP + rhDNase) or 100 µl PBS (CLP) 1, 4, 7, 10, 21, 24, and 27 hours after CLP. **P < 0.01, ***P < 0.001 versus adjacent time point; ###P < 0.001 versus CLP. CLP, cecal ligation and puncture; DNase, desoxyribonuclease; IL-6, interleukin-6; NETs, neutrophil extracellular traps; PBS, phosphate-buffered saline; rh, recombinant human.

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Critical Care

ISSN: 1364-8535