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Figure 3 | Critical Care

Figure 3

From: Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice

Figure 3

Influence of rhDNase treatment on NETs activity, neutrophil and platelet counts. cf-DNA/NETs (A) and DNase (B) levels as well as neutrophil (C) and platelet (D) counts in serum of mice at 6 (n = 5), 24 (n = 7), and 48 (n = 7) hours treated with either 5 mg/kg rhDNase or PBS 1, 4, 7, 10, 21, 24, and 27 hours after CLP. *P < 0.05, **P < 0.01, ***P < 0.001 versus adjacent time point within one group; ###P < 0.001 versus CLP without rhDNase. CLP, cecal ligation and puncture; DNase, desoxyribonuclease; NETs, neutrophil extracellular traps; PBS, phosphate-buffered saline; rh, recombinant human

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Critical Care

ISSN: 1364-8535