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Table 3 Operating characteristics of sST2 for predicting response to pulmonary artery catheter guided therapy

From: Measurement of multiple biomarkers in advanced stage heart failure patients treated with pulmonary artery catheter guided therapy

Outcome and cut-off point Sensitivity Specificity PPV NPV
CVP non-response     
   129 ng/mL (median) 83% 67% 63% 86%
   171 ng/mL (ROC optimal) 83% 78% 71% 88%
PCWP non-response     
   129 ng/mL (median) 67% 67% 75% 57%
   98 ng/mL (ROC optimal) 89% 58% 76% 78%
SVR non-response     
   129 ng/mL (median) 57% 50% 50% 57%
   105 ng/mL (ROC optimal) 71% 47% 53% 64%
  1. CVP, central venous pressure; NPV, negative predictive value; PPV, positive predictive value; PCWP, pulmonary capillary wedge pressure; ROC, receiver operator characteristic; sST2, soluble ST2; SVR, systemic vascular resistance.