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Table 1 Characteristics of the compared groups at baseline.

From: Metformin attenuates ventilator-induced lung injury

Variables LoP-C LoP-Met HiP-C HiP-Met
Animal weight, kg 3.2 ± 0.2 3.4 ± 0.2 3.3 ± 0.4 3.0 ± 0.3
Serum glucose, mg/dL 179 ± 44 182 ± 91 152 ± 93 144 ± 59
Initial lung weight, g 24.1 ± 2.4 24.4 ± 2.3 23.8 ± 2.5 20.6 ± 2.7
Ischemic time, minutes 34.6 ± 5.5 39.0 ± 7.1 39.0 ± 6.8 34.4 ± 4.9
Before the beginning of 60-minute ventilation   
PPAmean, mmHg 20.4 ± 3.5 24.8 ± 7.5* 16.8 ± 3.1* 16.7 ± 4.0*
PPAinspir, mmHg 24.9 ± 3.8 30.8 ± 8.4 22.5 ± 4.4 22.0 ± 4.4
PPAexpir, mmHg 18.4 ± 3.7 21.4 ± 6.7* 13.9 ± 2.7* 12.9 ± 2.2*
Pcap, mmHg 7.5 ± 1.8 7.0 ± 0.6 6.3 ± 0.4 6.8 ± 0.6
Kf,c, g/min/mmHg/100g 0.185±0.09 0.147±0.05 0.209±0.07 0.244±0.11
At the beginning of 60-minute ventilation:   
pH 7.33 ± 0.17 7.27 ± 0.09 7.32 ± 0.11 7.33 ± 0.07
PaO2, mmHg 161 ± 9** 154 ± 9 147 ± 2** 147 ± 8
PaCO2, mmHg 44.7 ± 19.9 47.2 ± 6.6 44.8 ± 5.4 44.7 ± 7.3
T, °C 35.9 ± 0.5 35.2 ± 0.8 36.2 ± 0.8 35.6 ± 0.5
  1. LoP-C: low pressure-no metformin; LoP-Met: low pressure-metformin; HiP-C: high pressure-no metformin; HiP-Met: high pressure-metformin; PPAmean: mean pulmonary arterial pressure; PPAinspir: inspiratory pulmonary arterial pressure; PPAexpir: expiratory pulmonary arterial pressure; Pcap: pulmonary capillary hydrostatic pressure; Kf,c: ultrafiltration coefficient; PaO2: arterial oxygen tension; PaCO2: arterial carbon dioxide tension; T: temperature. Results are presented as means ± standard deviation; n = 7 animals per HiP group and 5 animals per LoP group. *P < 0.01 for comparison between the LoP-Met and both HiP groups; **P < 0.05 for comparison between the LoP-C and HiP-C group.