Metformin attenuates ventilator-induced lung injury

Table 1 Characteristics of the compared groups at baseline.

Variables	LoP-C	LoP-Met	HiP-C	HiP-Met
Animal weight, kg	3.2 ± 0.2	3.4 ± 0.2	3.3 ± 0.4	3.0 ± 0.3
Serum glucose, mg/dL	179 ± 44	182 ± 91	152 ± 93	144 ± 59
Initial lung weight, g	24.1 ± 2.4	24.4 ± 2.3	23.8 ± 2.5	20.6 ± 2.7
Ischemic time, minutes	34.6 ± 5.5	39.0 ± 7.1	39.0 ± 6.8	34.4 ± 4.9
Before the beginning of 60-minute ventilation
PPAmean, mmHg	20.4 ± 3.5	24.8 ± 7.5*	16.8 ± 3.1*	16.7 ± 4.0*
PPAinspir, mmHg	24.9 ± 3.8	30.8 ± 8.4	22.5 ± 4.4	22.0 ± 4.4
PPAexpir, mmHg	18.4 ± 3.7	21.4 ± 6.7*	13.9 ± 2.7*	12.9 ± 2.2*
Pcap, mmHg	7.5 ± 1.8	7.0 ± 0.6	6.3 ± 0.4	6.8 ± 0.6
Kf,c, g/min/mmHg/100g	0.185±0.09	0.147±0.05	0.209±0.07	0.244±0.11
At the beginning of 60-minute ventilation:
pH	7.33 ± 0.17	7.27 ± 0.09	7.32 ± 0.11	7.33 ± 0.07
PaO₂, mmHg	161 ± 9**	154 ± 9	147 ± 2**	147 ± 8
PaCO₂, mmHg	44.7 ± 19.9	47.2 ± 6.6	44.8 ± 5.4	44.7 ± 7.3
T, °C	35.9 ± 0.5	35.2 ± 0.8	36.2 ± 0.8	35.6 ± 0.5

LoP-C: low pressure-no metformin; LoP-Met: low pressure-metformin; HiP-C: high pressure-no metformin; HiP-Met: high pressure-metformin; PPAmean: mean pulmonary arterial pressure; PPAinspir: inspiratory pulmonary arterial pressure; PPAexpir: expiratory pulmonary arterial pressure; Pcap: pulmonary capillary hydrostatic pressure; Kf,c: ultrafiltration coefficient; PaO₂: arterial oxygen tension; PaCO₂: arterial carbon dioxide tension; T: temperature. Results are presented as means ± standard deviation; n = 7 animals per HiP group and 5 animals per LoP group. *P < 0.01 for comparison between the LoP-Met and both HiP groups; **P < 0.05 for comparison between the LoP-C and HiP-C group.

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