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Table 4 Clinical relevance of four variants among trauma patients

From: Identification of haplotype tag single nucleotide polymorphisms within the receptor for advanced glycation end products gene and their clinical relevance in patients with major trauma

  Polymorphic sites Genotypes N Age (yr) Sex (M/F) ISS Sepsis, n/% MOD score
Chongqing   ins/ins 423 40.2 ± 14.6 334/89 22.3 ± 10.5 178 (42.1) 6.4 ± 2.4
  63 bp ins/del ins/del 70 40.9 ± 11.1 59/11 20.5 ± 10.5 23 (32.9) 6.1 ± 2.8
   del/del 3 47.3 ± 18.8 2/1 24.3 ± 8.5 1 (33.3) 6.0 ± 1.7
   GG 247 39.5 ± 14.4 198/49 22.2 ± 11.4 100 (40.5) 6.7 ± 2.6
  rs2070600 GA 206 41.0 ± 14.4 161/45 21.9 ± 9.4 84 (40.8) 6.1 ± 2.3
   AA 43 42.5 ± 11.5 36/7 22.0 ± 10.4 18 (41.9) 5.7 ± 1.6
   TT 364 40.4 ± 14.3 291/73 22.2 ± 10.4 148 (40.7) 6.3 ± 2.4
  rs1800624 TA 117 40.5 ± 14.3 91/26 21.7 ± 11.0 51 (43.6) 6.5 ± 2.5
   AA 15 39.7 ± 12.0 13/2 20.2 ± 8.8 3 (20.0) 7.0 ± 2.6
   TT 365 40.0 ± 14.1 291/74 22.4 ± 10.5 163 (44.7) 6.9 ± 2.4
  rs1800625 TC 116 42.4 ± 14.4 89/27 21.3 ± 10.7 35 (30.2) 6.0 ± 2.2
   CC 15 37.3 ± 9.9 15/0 17.2 ± 9.8 4 (26.7) 5.3 ± 1.5
        a1 a2, b1, c1
Zhejiang   ins/ins 203 41.0 ± 12.9 165/38 23.3 ± 8.6 74 (36.4) 6.9 ± 3.4
  63bp ins/del ins/del 29 41.1 ± 14.9 25/4 22.7 ± 9.3 14 (48.3) 8.4 ± 3.0
   del/del 0 - - - 0 (0) -
   GG 126 41.3 ± 13.4 102/24 22.7 ± 8.6 48 (38.1) 7.1 ± 3.1
  rs2070600 GA 85 40.7 ± 12.4 70/15 23.0 ± 8.5 35 (41.2) 6.9 ± 3.6
   AA 21 40.6 ± 14.5 18/3 27.5 ± 8.6 5 (23.8) 6.9 ± 2.8
  rs1800624 TT 181 41.0 ± 13.3 150/31 23.4 ± 8.7 70 (38.7.) 7.0 ± 3.5
   TA 48 40.6 ± 13.0 38/10 22.4 ± 8.3 16 (33.3) 7.4 ± 3.2
   AA 3 44.7 ± 7.1 2/1 28.0 ± 14.1 2 (67.7) 6.7 ± 2.3
   TT 163 41.4 ± 13.2 138/25 23.7 ± 8.5 70 (42.9) 7.3 ± 3.3
  rs1800625 TC 64 40.9 ± 13.2 47/17 21.8 ± 8.6 16 (25.0) 6.9 ± 3.2
   CC 5 37.7 ± 15.7 4/1 24.3 ± 12.0 2 (40.0) 6.3 ± 2.5
        a3 a4, c2
  1. A, dominant effect (variant homozygotes +heterozygotes vs. wild homozygotes) as analyzed by ANOVA, a1P = 0.003, a2P = 0.015, a3P = 0.016, a4P = 0.042; b, recessive effect (variant homozygotes vs. heterozygotes + wild homozygotes); as analyzed by ANOVA, b1P = 0.032; c, Allele Dose Effect as analyzed by linear regression, c1P = 0.045, c2P = 0.048.