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Table 3 Cumulative 30-day mortality and corresponding adjusted hazard ratios (HRs)

From: One-year mortality among Danish intensive care patients with acute kidney injury: a cohort study

   Without AKI With AKI
  Number Cumulative mortality
% (95% CI)
Adjusted HR
(95% CI)
Cumulative mortality
% (95% CI)
Adjusted HRa
(95% CI)
Overall 30,762 12.8 (12.4-13.2) 1 (reference) 39.6 (38.2-41.0) 2.27 (2.14-2.40)
Age group, years      
   ≥ 15 < 40 4,670 2.5 (2.1-3.0) 1 (reference) 16.8 (12.8-21.9) 4.87 (3.33-7.13)
   ≥ 40 < 60 7,397 7.6 (7.0-8.3) 1 (reference) 29.2 (26.4-32.2) 3.18 (2.72-3.70)
   ≥ 60 < 80 14,184 14.1 (13.5-14.8) 1 (reference) 39.1 (37.2-41.1) 2.28 (2.11-2.47)
   ≥ 80 4,511 31.4 (29.9-33.0) 1 (reference) 55.1 (52.2-58.1) 1.83 (1.65-2.02)
Charlson comorbidity index score a      
   Low (score 0) 15,726 9.0 (8.5-9.4) 1 (reference) 35.0 (32.9-37.2) 2.55 (2.31-2.81)
   Medium (score 1 to 2) 10,544 15.7 (15.0-16.5) 1 (reference) 41.4 (39.2-43.6) 2.17 (1.99-2.38)
   High (score ≥ 3) 4,492 21.1 (19.8-22.5) 1 (reference) 44.5 (42.0-47.5) 1.96 (1.74-2.20)
Surgical status c, d      
   Non-surgical 11,766 16.7 (16.0-17.5) 1 (reference) 41.7 (39.7-43.7) 2.01 (1.85-2.18)
   Surgical      
Acute non-cardiac 10,141 15.9 (15.2-16.7) 1 (reference) 42.0 (40.8-44.3) 2.40 (2.20-2.63)
Acute cardiac 1,096 15.8 (13.6-18.3) 1 (reference) 44.3 (37.3-52.0) 3.27 (2.48-4.31)
Elective non-cardiac 4,334 5.4 (4.8-6.2) 1 (reference) 20.5 (16.9-24.8) 3.43 (2.65-4.45)
Elective cardiac 3,425 1.9 (1.5-2.4) 1 (reference) 7.4 (3.4-5.8) 3.76 (1.62-8.77)
Primary diagnosis during current hospitalization      
   Septicemia 646 38.8 (32.9-45.4) 1 (reference) 52.2 (47.5-57.1) 1.53 (1.19-1.96)
   Other infectious diseases 2,959 15.0 (13.6-16.5) 1 (reference) 36.5 (32.9-40.4) 1.97 (1.66-2.33)
   Endocrinology diseases 558 7.2 (5.0-10.5) 1 (reference) 17.1 (12.5-23.1) 1.89 (1.11-3.19)
   Cardiovascular diseases 8,220 13.8 (13.0-14.6) 1 (reference) 44.3 (41.0-47.7) 2.14 (1.89-2.41)
   Respiratory diseases 1,750 27.8 (25.5-30.2) 1 (reference) 47.1 (41.8-52.7) 1.76 (1.46-2.13)
   Gastrointestinal or liver diseases 3,243 17.1 (15.6-18.6) 1 (reference) 41.7 (38.4-45.2) 2.54 (2.20-2.93)
   Cancer or other neoplasm 3,854 10.3 (9.3-11.4) 1 (reference) 34.5 (30.2-39.1) 2.59 (2.12-3.16)
   Trauma or poisoning 5,035 7.6 (6.9-8.4) 1 (reference) 32.6 (28.1-37.6) 2.41 (1.95-2.99)
   Other 4,497 8.8 (8.0-9.8) 1 (reference) 36.7 (33.3-40.3) 2.62 (2.22-3.09)
Chronic kidney disease b      
   Yes 4,347 24. 1 (22.7-25.6) 1 (reference) 44.3 (41.3-47.3) 1.80 (1.60-2.02)
   No 26,415 11.2 (10.7-11.6) 1 (reference) 38.2 (36.7-39.8) 2.45 (2.30-2.63)
ICU treatments      
   Mechanical ventilation 12,054 20.5 (19.5-21.6) 1 (reference) 46.2 (44.2-48.2) 1.60 (1.48-1.72)
   Inotropes/vasopressors 10,382 19.3 (18.4-20.2) 1 (reference) 46.2 (44.3-48.2) 1.77 (1.63-1.91)
  1. aCompared to patients without AKI within subgroups and adjusted for age, gender, Charlson comorbidity index score, surgical status, and chronic kidney disease.
  2. beGFR < 60 ml/min per 1.73 m2.
  3. cSurgical status and cardiac surgical status identified by surgery and type of surgery on or up to 7 days before ICU admission, respectively.
  4. dAcute and elective status classified according to hospital admission type
  5. AKI, acute kidney injury; CI, confidence interval; HR, hazard ratio; ICU, intensive care unit.