Skip to main content

Table 5 Statin use and pneumonia risk and mortality within various patient subgroups

From: The impact of statin use on pneumonia risk and outcome: a combined population-based case-control and cohort study

Variables

Risk of hospitalization for pneumonia, OR (95% CI)

30-day mortality after hospitalization for pneumonia, HR (95% CI)

Main model for 1997-2009

Current statin use

Former statin use

Current statin use

Former statin use

Calendar time

    

   1997-2000

0.77 (0.68-0.88)

1.12 (0.84-1.49)

0.57 (0.38-0.85)

1.04 (0.52-2.10)

   2001-2004

0.79 (0.74-0.85)

0.88 (0.77-1.00)

0.70 (0.59-0.83)

0.95 (0.70-1.29)

   2005-2009

0.81 (0.77-0.84)

0.98 (0.92-1.05)

0.74 (0.67-0.82)

0.90 (0.78-1.03)

Charlson comorbidity index score

    

   Low, 0

0.78 (0.72-0.84)

1.03 (0.90-1.18)

0.73 (0.56-0.94)

0.77 (0.48-1.22)

   Medium, 1-2

0.74 (0.70-0.78)

0.83 (0.76-0.91)

0.73 (0.64-0.83)

0.79 (0.63-0.98)

   High, ≥3

0.74 (0.68-0.81)

0.90 (0.79-1.04)

0.69 (0.61-0.77)

0.93 (0.79-1.09)

Age

    

   15-39 years

0.98 (0.60-1.60)

0.82 (0.42-1.60)

0.00

0.00

   40-64 years

0.78 (0.72-0.84)

1.07 (0.95-1.21)

0.77 (0.61-0.97)

0.89 (0.65-1.21)

   65-79 years

0.74 (0.71-0.78)

0.91 (0.84-0.99)

0.69 (0.61-0.78)

0.85 (0.71-1.02)

   ≥80 years

0.80 (0.75-0.85)

0.85 (0.76-0.95)

0.75 (0.66-0.85)

0.95 (0.77-1.16)

   Patients with indication for statin usea

0.70 (0.67-0.73)

0.78 (0.72-0.85)

0.70 (0.64-0.77)

0.86 (0.75-1.00)

Supplementary adjusted model for 2001-2009

    

   Receipt of current year's influenza vaccine before index date

0.78 (0.72-0.85)

0.89 (0.78-1.01)

0.76 (0.65-0.88)

0.92 (0.72-1.18)

   Preventive GP consultations and services

0.77 (0.69-0.86)

1.10 (0.94-1.29)

0.80 (0.66-0.97)

0.92 (0.70-1.19)

   Social medicine-related GP consultations

0.73 (0.66-0.81)

0.91 (0.77-1.08)

0.82 (0.72-0.94)

0.96 (0.79-1.18)

   GP conversational therapy

0.80 (0.61-1.04)

0.87 (0.59-1.29)

0.89 (0.67-1.19)

0.66 (0.41-1.05)

   Application for reimbursement for chronic illness

0.43 (0.23-0.81)

0.43 (0.16-1.22)

0.64 (0.47-0.86)

0.86 (0.54-1.35)

  1. aPrevious diagnosis of ischemic or unspecified stroke, ischemic heart disease, atherosclerosis, or diabetes mellitus. For International Classification of Diseases (ICD) codes, see Additional file 4. Adjusted pneumonia hospitalization odds ratios (ORs) (case-control study) and 30-day mortality hazard ratios (HRs) (cohort study) associated with current and former use of statins are shown. CI, confidence interval; GP, general practitioner.