Table 5 Adrenal dysfunction of critical illness-related corticosteroid insufficiency on ACTH test day

ACTH, pM

2.8 (4.6)

4.0 (11)

1.1 (1.8)

2.5 (2.6)

0.02, 0.001, 0.27

Cholesterol, mM

1.6 (1.5)

1.6 (1.0)

1.4 (0.7)

2.5 (1.0)

0.03, 0.06, 0.07

HDL-cholesterol, mM

0.60 (0.30)

0.40 (0.40)

0.40 (0.50)

0.90 (0.50)

0.09, 0.13, 0.04

Progesterone, nM

0.90 (1.5)

0.70 (0.80)

0.40 (0.70)

0.60 (0.60)

0.63, 0.83, 0.39

Corticosterone, nM

2.6 (3.1)

4.3 (8.0)

6.0 (7.2)

3.3 (6.5)

0.71, 0.71, 0.06

Aldosterone, nM

0.90 (1.2)

0.90 (1.3)

1.5 (1.3)

1.0 (1.3)

0.34, 0.95, 0.90

17-OH-progesterone, nM

3.2 (2.3)

2.5 (2.4)

2.5 (3.2)

2.6 (1.5)

0.10, 0.16, 0.12

11ß-deoxycortisol, nM

25 (56)

2.8 (11)

17 (45)

2.0 (4.9)

0.26, 0.05, 0.50

Cortisol, nM

427 (192)

518 (294)

460 (230)

460 (310)

0.64, 0.70, 0.06

Cortisol/11ß-deoxycortisol

13 (139)

177 (400)

38 (170)

229 (372)

0.15, < 0.001, 0.96

Cortisol/ACTH

180 (120)

107 (154)

395 (376)

165 (227)

< 0.001, < 0.001, 0.004

Cortisol increase, nM

121 (114)

180 (118)

280 (30)

440 (163)

na, < 0.001, na

DHEA, μM

6.4 (2.6)

6.1 (5.6)

5.5 (4.1)

6.1 (3.9)

0.88, 0.48, 0.80

DHEAS, nM

1.0 (2.5)

0.48 (1.1)

0.55 (0.98)

0.59 (0.90)

0.55, 0.03, 0.16

Androstenedione, nM

3.7 (8.7)

2.9 (3.8)

3.6 (5.6)

2.2 (2.4)

0.23, 0.93, 0.19