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Table 3 Sepsis and nonsepsis on ACTH test day, and etomidate, no etomidate, and other variables before the ACTH test

From: Steroidogenesis in the adrenal dysfunction of critical illness: impact of etomidate

 

Sepsis

Nonsepsis

P

 

Etomidate

No etomidate

Etomidate

No etomidate

 
 

n = 11

n = 32

n = 3

n = 21

S, E, E*S

Days admission to test

1 (2)

3 (9)

1 (2)

12 (17)

0.11, < 0.001, 0.06

APACHE II

17 (8)

18 (6)

17 (10)

14 (7)

0.29, 0.56, 0.73

Focus sepsis

   Respiratory

4 (36)

18 (56)

-

-

na, 0.52, na

   Abdominal

4 (36)

6 (19)

-

-

   Genitourinary

-

1 (3)

-

-

   Soft tissue

1 (9)

3 (9)

-

-

   Endocarditis

1 (9)

-

-

-

   Meningitis

-

1 (3)

-

-

   Unknown

1 (9)

3 (9)

-

-

Bacteria involved

    

na, 0.59, na

   Gram+

2

3

-

-

   Gram-

3

13

-

-

   Mixed and others

1

1

-

-

   Gram bacteremia-

 

4

-

-

na, 0.83, na

   Gram bacteremia+

1

3

-

-

Mechanical ventilation

11 (100)

28 (88)

3 (100)

15 (71)

1.0, 0.98, 1.0

Renal replacement therapy

2 (18)

9 (28)

1 (33)

1 (5)

0.31, 0.54, 0.13

MAP, mm Hg

76 (17)

73 (17)

70 (14)

91 (21)

0.02, < 0.001, < 0.001

Norepinephrine

11 (100)

22 (69)

2 (67)

9 (43)

0.005, < 0.001, 0.07

Dopamine

0

2 (6)

1 (33)

3 (14)

0.15, 0.66, 0.37

  1. Data are expressed as median (interquartile range) or number (%), where appropriate. APACHE, Acute Physiology, Age and Chronic Health Evaluation; MAP, mean arterial pressure; S, sepsis; E, etomidate; E*S, interaction between the two in generalized estimating equations; na, not applicable.