From: Steroidogenesis in the adrenal dysfunction of critical illness: impact of etomidate
 | Sepsis | Nonsepsis | P | ||
---|---|---|---|---|---|
 | Etomidate | No etomidate | Etomidate | No etomidate |  |
 | n = 11 | n = 32 | n = 3 | n = 21 | S, E, E*S |
Days admission to test | 1 (2) | 3 (9) | 1 (2) | 12 (17) | 0.11, < 0.001, 0.06 |
APACHE II | 17 (8) | 18 (6) | 17 (10) | 14 (7) | 0.29, 0.56, 0.73 |
Focus sepsis | |||||
   Respiratory | 4 (36) | 18 (56) | - | - | na, 0.52, na |
   Abdominal | 4 (36) | 6 (19) | - | - | |
   Genitourinary | - | 1 (3) | - | - | |
   Soft tissue | 1 (9) | 3 (9) | - | - | |
   Endocarditis | 1 (9) | - | - | - | |
   Meningitis | - | 1 (3) | - | - | |
   Unknown | 1 (9) | 3 (9) | - | - | |
Bacteria involved | Â | Â | Â | Â | na, 0.59, na |
   Gram+ | 2 | 3 | - | - | |
   Gram- | 3 | 13 | - | - | |
   Mixed and others | 1 | 1 | - | - | |
   Gram bacteremia- |  | 4 | - | - | na, 0.83, na |
   Gram bacteremia+ | 1 | 3 | - | - | |
Mechanical ventilation | 11 (100) | 28 (88) | 3 (100) | 15 (71) | 1.0, 0.98, 1.0 |
Renal replacement therapy | 2 (18) | 9 (28) | 1 (33) | 1 (5) | 0.31, 0.54, 0.13 |
MAP, mm Hg | 76 (17) | 73 (17) | 70 (14) | 91 (21) | 0.02, < 0.001, < 0.001 |
Norepinephrine | 11 (100) | 22 (69) | 2 (67) | 9 (43) | 0.005, < 0.001, 0.07 |
Dopamine | 0 | 2 (6) | 1 (33) | 3 (14) | 0.15, 0.66, 0.37 |