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Table 3 Sepsis and nonsepsis on ACTH test day, and etomidate, no etomidate, and other variables before the ACTH test

From: Steroidogenesis in the adrenal dysfunction of critical illness: impact of etomidate

  Sepsis Nonsepsis P
  Etomidate No etomidate Etomidate No etomidate  
  n = 11 n = 32 n = 3 n = 21 S, E, E*S
Days admission to test 1 (2) 3 (9) 1 (2) 12 (17) 0.11, < 0.001, 0.06
APACHE II 17 (8) 18 (6) 17 (10) 14 (7) 0.29, 0.56, 0.73
Focus sepsis
   Respiratory 4 (36) 18 (56) - - na, 0.52, na
   Abdominal 4 (36) 6 (19) - -
   Genitourinary - 1 (3) - -
   Soft tissue 1 (9) 3 (9) - -
   Endocarditis 1 (9) - - -
   Meningitis - 1 (3) - -
   Unknown 1 (9) 3 (9) - -
Bacteria involved      na, 0.59, na
   Gram+ 2 3 - -
   Gram- 3 13 - -
   Mixed and others 1 1 - -
   Gram bacteremia-   4 - - na, 0.83, na
   Gram bacteremia+ 1 3 - -
Mechanical ventilation 11 (100) 28 (88) 3 (100) 15 (71) 1.0, 0.98, 1.0
Renal replacement therapy 2 (18) 9 (28) 1 (33) 1 (5) 0.31, 0.54, 0.13
MAP, mm Hg 76 (17) 73 (17) 70 (14) 91 (21) 0.02, < 0.001, < 0.001
Norepinephrine 11 (100) 22 (69) 2 (67) 9 (43) 0.005, < 0.001, 0.07
Dopamine 0 2 (6) 1 (33) 3 (14) 0.15, 0.66, 0.37
  1. Data are expressed as median (interquartile range) or number (%), where appropriate. APACHE, Acute Physiology, Age and Chronic Health Evaluation; MAP, mean arterial pressure; S, sepsis; E, etomidate; E*S, interaction between the two in generalized estimating equations; na, not applicable.