Pancreatic stone protein as an early biomarker predicting mortality in a prospective cohort of patients with sepsis requiring ICU management

Table 3 Plasma concentrations of biomarkers and severity scores, by survival status

Biomarker or severity scoring system	All (n= 107)
	Death ( n = 22)		Survival ( n = 85)
	Median	IQR	Median	IQR	P value
Acute-phase proteins
CRP, mg/L	203	188	266	154	0.21
PCT, ng/mL	17.485	51.75	26.22	44.75	0.57
PSP/reg, ng/mL	397	435.9	216.1	379	0.02
Cytokines
TNF-α, pg/ml	2.655	10.36	2.35	6.73	0.46
IL-1β, pg/mL	0.795	34.02	7.6	20.41	0.46
IL-6, pg/mL	2,415.58	16,219.42	790.53	6,467.74	0.16
IL-8, pg/mL	757.775	10,597.73	414.88	1,597.6	0.11
IL-10, pg/mL	416.18	1393.6	136.76	494.89	0.17
Other
Leukocytes, G/L	13.85	14.45	13.4	14.2	0.27
APACHE II	32	12	27	13	0.4
SAPS II	71.5	26	68	27	0.52
SAPS III	87.5	27	74	25	0.01
SOFA	11	6	11	4	0.9

APACHE II, Acute Physiology and Chronic Health Evaluation II; CRP, C-reactive protein; IL, interleukin; IQR, interquartile range; PCT, procalcitonin; PSP/reg, pancreatic stone protein/regenerating protein; SAPS, Simplified Acute Physiology Score; SOFA, Sequential Organ Failure Assessment; TNF-α, tumor necrosis factor-alpha.

ISSN: 1364-8535