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Table 2 Plasma concentrations of biomarkers and severity scores, by sepsis severity

From: Pancreatic stone protein as an early biomarker predicting mortality in a prospective cohort of patients with sepsis requiring ICU management

Biomarker or severity scoring system All (n= 107) Severe sepsis (n= 33) Septic shock (n= 74)  
  Median IQR Median IQR Median IQR Test
Acute-phase proteins        
   CRP, mg/L 253.5 155.5 218 152 266 158 0.35
   PCT, ng/mL 25.12 48.98 11.96 20.94 39.25 49.99 < 0.0001
   PSP/reg, ng/mL 241.25 399.00 73.5 180.25 343.5 369 < 0.0001
Cytokines        
   TNF-α, pg/ml 2.47 7.07 1.93 7.07 2.41 6.97 0.86
   IL-1β, pg/mL 6.43 21.04 1.96 15.53 8.175 24.54 0.21
   IL-6, pg/mL 1,173.28 6,749.6 544.07 1,237.48 1,755.34 14,514.13 0.004
   IL-8, pg/mL 438.95 1,804.67 184.15 408.72 681.775 3,273.42 0.0001
   IL-10, pg/mL 149.37 672.82 76.24 239.67 199.94 706.22 0.045
Other        
   Leukocytes, G/L 13.5 14.2 13.5 5.5 13.3 17.1 0.28
   APACHE II 28 14 26 14 29 14 0.04
   SAPS II 69 26 62 29 71 27 0.02
   SAPS III 76 27 69 28 79.5 25 0.001
   SOFA 11 4 10 5 11 5 0.35
  1. APACHE II, Acute Physiology and Chronic Health Evaluation II; CRP, C-reactive protein; IL, interleukin; IQR, interquartile range; PCT, procalcitonin; PSP/reg, pancreatic stone protein/regenerating protein; SAPS, Simplified Acute Physiology Score; SOFA, Sequential Organ Failure Assessment; TNF-α, tumor necrosis factor-alpha.