Pancreatic stone protein as an early biomarker predicting mortality in a prospective cohort of patients with sepsis requiring ICU management

Table 2 Plasma concentrations of biomarkers and severity scores, by sepsis severity

Biomarker or severity scoring system	All (n= 107)		Severe sepsis (n= 33)		Septic shock (n= 74)
	Median	IQR	Median	IQR	Median	IQR	Test
Acute-phase proteins
CRP, mg/L	253.5	155.5	218	152	266	158	0.35
PCT, ng/mL	25.12	48.98	11.96	20.94	39.25	49.99	< 0.0001
PSP/reg, ng/mL	241.25	399.00	73.5	180.25	343.5	369	< 0.0001
Cytokines
TNF-α, pg/ml	2.47	7.07	1.93	7.07	2.41	6.97	0.86
IL-1β, pg/mL	6.43	21.04	1.96	15.53	8.175	24.54	0.21
IL-6, pg/mL	1,173.28	6,749.6	544.07	1,237.48	1,755.34	14,514.13	0.004
IL-8, pg/mL	438.95	1,804.67	184.15	408.72	681.775	3,273.42	0.0001
IL-10, pg/mL	149.37	672.82	76.24	239.67	199.94	706.22	0.045
Other
Leukocytes, G/L	13.5	14.2	13.5	5.5	13.3	17.1	0.28
APACHE II	28	14	26	14	29	14	0.04
SAPS II	69	26	62	29	71	27	0.02
SAPS III	76	27	69	28	79.5	25	0.001
SOFA	11	4	10	5	11	5	0.35

APACHE II, Acute Physiology and Chronic Health Evaluation II; CRP, C-reactive protein; IL, interleukin; IQR, interquartile range; PCT, procalcitonin; PSP/reg, pancreatic stone protein/regenerating protein; SAPS, Simplified Acute Physiology Score; SOFA, Sequential Organ Failure Assessment; TNF-α, tumor necrosis factor-alpha.

ISSN: 1364-8535