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Table 1 Patient characteristics, by sepsis severity (n = 107)

From: Pancreatic stone protein as an early biomarker predicting mortality in a prospective cohort of patients with sepsis requiring ICU management

Patient characteristic All Severe sepsis Septic shock
  ( n = 107) ( n = 33) ( n = 74)
Demographics    
   Age in years, mean ± SD 59 ± 17.5 55 ± 20 61 ± 16
   Male/Female 62/45 20/13 42/32
Admission categories    
   Medical 72 (67%) 24 (73%) 48 (65%)
   Scheduled surgery 4 (4%) 0 (0%) 4 (5%)
   Unscheduled surgery 31 (29%) 9 (27%) 22 (30%)
Origin    
   Community (home/emergency room) 61 (57%) 18 (54.5%) 43 (58.1%)
   Nosocomial (hospital transfer) 46 (43%) 15 (45.5%) 31 (41.9%)
Referral from other hospital 20 (18.7%) 5 (15.2%) 15 (20.3%)
Operating room 3 (2.8%) 1 (3%) 2 (2.7%)
Ward 14 (13.1%) 6 (18.2%) 8 (10.8%)
Intermediate care 9 (8.4%) 3 (9.1%) 6 (8.1%)
Severe comorbidities    
   Chronic obstructive pulmonary disease 17 (15.8%) 5 (15.1%) 12 (16.2%)
   Cardiac insufficiency 16 (15%) 2 (6%) 14 (18.9%)
   Cirrhosis 8 (7.5%) 1 (3%) 7 (9.5%)
   End-stage renal disease 15 (14%) 3 (9%) 12 (16.2%)
   Immunodeficiencya 13 (12.1%) 2 (6%) 11 (14.9%)
   Insulin-dependent diabetes 6 (5.6%) 1 (3%) 5 (6.7%)
Score, mean ± SD    
   APACHE II 30 ± 8 27 ± 86 31 ± 8
   SAPS II 71 ± 17 65 ± 16 74 ± 17
   SAPS III 76 ± 18 67 ± 21 80 ± 15
   SOFA (day 1) 11 ± 3 11 ± 3 11 ± 3
McCabe score    
   Non-fatal 63 (59%) 22 (66.6%) 41 (55%)
   Ultimately fatal (< 5 years) 30 (28%) 7 (21.2%) 23 (31%)
   Rapid fatal (< 6 months) 14 (13%) 4 (12.2%) 10 (14%)
Infection sites    
   Pulmonary 37 (34.5%) 14 (42.4%) 23 (31%)
   Abdominal 38 (36%) 7 (21.2%) 31 (41.9%)
   Bloodstream 7 (6.5%) 4 (12.1%) 3 (4.1%)
   CNS and ENT 5 (4.6%) 2 (6.1%) 3 (4.1%)
   Urinary tract 5 (4.6%) 2 (6.1%) 3 (4.1%)
   Soft tissues 13 (12%) 4 (12.1%) 9 (12.1%)
   Miscellaneous 2 (1.8%) 0 (0%) 2 (2.7%)
Microbiology    
   Gram-positive (number of positive blood cultures) 41 (38.3%) 17 (51.5%) 24 (32.4%)
Staphylococcus aureus (8) 8 (7.5%) 5 (15.1%) 3 (4.1%)
Streptococcus pyogenes (2) 10 (9.3%) 2 (6.1%) 8 (10.8%)
Streptococcus pneumoniae (8) 20 (18.7%) 8 (24.2%) 12 (16.1%)
Other (2) 3 (2.8%) 2 (6.1%) 1 (1.4%)
   Gram-negative 45 (42%) 13 (39.4%) 32 (43.2%)
Escherichia coli (14) 23 (21.5%) 5 (15.2%) 18 (24.3%)
Other Enterobacteriacae (5) 7 (6.5%) 1 (3.05%) 6 (8.1%)
Pseudomonas aeruginosa (5) 6 (5.6%) 3 (9.05%) 3 (4.1%)
Other (5) 9 (8.4%) 4 (12.1%) 5 (6.7%)
   Fungi 3 (2.8%) 0 (0%) 3 (4.1%)
Candida albicans (1) 1 (1%) 0 (0%) 1 (1.4%)
Other (0) 2 (1.8%) 0 (0%) 2 (2.7%)
   H1N1 1 (1%) 0 (0%) 1 (1.4%)
   Undocumented 17 (15.9%) 3 (9.1%) 14 (18.9%)
Outcome    
   Hospital mortality 22 (20.6%) 3 (9%) 19 (25.7%)
  1. Values are presented as numbers (percentages) of patients unless indicated otherwise. aHIV, solid organ transplant recipients, hematological malignancies, chronic use of more than 30 mg per day prednisone equivalents. APACHE II, Acute Physiology and Chronic Health Evaluation II; CNS, central nervous system; ENT, ear, nose, and throat; SAPS, Simplified Acute Physiology Score; SD, standard deviation; SOFA, Sequential Organ Failure Assessment.