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Table 2 Bacterial isolates and susceptibility characteristics to meropenem in clinically evaluable population

From: Clinical and microbiological efficacy of continuous versus intermittent application of meropenem in critically ill patients: a randomized open-label controlled trial

 

Number n (%)

MIC (mg/l)

Pathogen1

Infusion group

n = 106

Bolus group

n = 108

P

Infusion group

n = 106

Bolus group

n = 108

P

None cultured

10 (9.4%)

6 (5.6%)

0.310

n/a

n/a

n/a

Acinetobacter spp.

8 (7.5%)

12 (11.1%)

0.482

2.000 (1.000 to 2.000)

1.500 (1.500 to 2.000)

0.635

Citrobacter spp.

3 (2.8%)

4 (3.7%)

1.000

0.190 (0.092 to 0.422)

0.125 (0.040 to 0.470)

0.724

Enterobacter spp.

3 (2.8%)

7 (6.5%)

0.332

0.190 (0.093 to 0.331)

0.060 (0.053 to 0.090)

0.170

Escherichia coli

6 (5.7%)

9 (8.3%)

0.594

0.090 (0.090 to 0.120)

0.120 (0.072 to 0.380)

0.260

Klebsiella spp.

63 (59.4%)

50 (46.3%)

0.057

0.120 (0.090 to 0.130)

0.090 (0.060 to 0.130)

0.205

Morganella morganii

3 (2.8%)

5 (4.6%)

0.721

0.250 (0.250 to 0.542)

0.320 (0.250 to 0.535)

0.760

Pseudomonas aeruginosa

4 (3.8%)

6 (5.6%)

0.748

2.000 (1.750 to 2.000)

1.750 (1.000 to 2.000)

0.363

Serratia marcescens

4 (3.8%)

6 (5.6%)

0.748

0.110 (0.094 to 0.222)

0.125 (0.094 to 0.190)

0.830

Stenotrophomonas maltophilia

2 (1.9%)

3 (2.8%)

1,000

2.000 (2.000 to 2.000)

2.000 (1.625 to 2.000)

0.519

MIC of all microorganisms

   

0.125 (0.090 to 0.640)

0.130 (0.090 to 0,350)

0.970

  1. Values are presented as absolute (percentage) or median (interquartile range).
  2. 1 Isolates do not include all pathogens, but those treated with meropenem; MIC, minimum inhibitory concentration; n/a, not applicable