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Table 1 Clinical characteristics of the patients at the time of starting CRRT and RCA-CVVH initial parameters.

From: Regional citrate anticoagulation in cardiac surgery patients at high risk of bleeding: a continuous veno-venous hemofiltration protocol with a low concentration citrate solution

Number = 33 (24 men, 9 women)  
Age (years) 70.8 ± 9.5 (range 46 to 85)
Creatinine (mg/dl) 2.5 ± 0.9
Blood urea nitrogen (mg/dl) 54.3 ± 26.2
Mean arterial pressure (mmHg) 72.5 ± 10.2
Oliguric AKIa 94%
Mechanical ventilation 100%
Total parenteral or enteral nutrition 100%
Use of vasopressors or inotropes 75.8%
APACHE II score 32.1 ± 4.6
SOFA score 13.9 ± 2.5
MELD score 18.7 ± 4.7
Bilirubin (mg/dl) 1.68 ± 1.98
Cardiovascular surgery:  
   Coronary artery bypass grafting 33.3%
   Coronary artery bypass grafting + valvular surgery 27.3%
   Ascending aorta replacement 24.2%
   Valvular surgery 15.2%
RCA-CVVH initial parameters b  
Prescribed dialysis dose, corrected for pre-dilution (ml/kg/hour) 28.1 ± 2.9
Blood flow rate (ml/minute) 135.7 ± 14.6
Pre-dilution citrate solution flow rate (l/hour) 1.69 ± 0.23
Post-dilution bicarbonate solution flow rate (l/hour) 0.77 ± 0.17
Calcium chloride 10% (mmol/hour) 2.38 ± 0.77
Citrate infusion rate (mmol/hour) 20.3 ± 2.8
Estimated citrate load (mmol/hour) 11.5 ± 2
  1. Data are expressed as mean ± SD or percentage. aAccording to AKIN criteria (Crit Care 2007; 11:R31). bData derived from the first RCA-CVVH session for each patient. AKI, acute kidney injury; AKIN, Acute Kidney Injury Network; APACHE, Acute Physiology and Chronic Health Evaluation; CRRT, continuous renal replacement therapy; MELD, Model for End-Stage Liver Disease; RCA-CVVH, regional citrate anticoagulation-continuous veno-venous hemofiltration; SD, standard deviation; SOFA, Sequential Organ Failure Assessment.