Table 1 Definitions

Creatinine Clearance

CCl

(Urine creatinine concentration/Plasma creatinine concentration) × (Volume of urine collected over 4 hours in ml/(4 × 60))

Cockcroft-Gault clearance [17]

CG

[(140-Age in years) × weight in kg/(72 × Plasma creatinine concentration in mg/dl)] × 0.85 if female

Average urine output

UO

Volume of urine collected over 4 hours in ml/(4 × Patient weight in kg)

Change in CCl

ΔCCl

100 × (Measured CG on entry - baseline CCl)/Baseline CG

Change in plasma creatinine

ΔpCr

100 × (On entry creatinine - baseline creatinine)/Baseline creatinine

AKI plasma creatinine

ΔpCr_AKI

ΔpCr > 50%

AKI creatinine clearance

ΔCCl_AKI

ΔCCl < -33.3%

AKI urine output (oliguria)

UO_AKI

Urine output < 0.5 ml/kg/hr on average over 4 hours

RIFLE class R

R

ΔpCr > 50% and ≤ 100%, or ΔCCl < -33.3% and ≥ -50%

RIFLE class I

I

ΔpCr > 100% and ≤ 200%, or ΔCCl < -50% and ≥ -66.7%

RIFLE class F

F

ΔpCr > 200% or ΔCCl < -66.7%

AKI from entry (AKIN)

AKI_AKIN

(Plasma creatinine - on entry plasma creatinine) > 0.3 mg/dl or 50% within 48 hours