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Table 1 Baseline characteristics and concomitant therapies at start of continuous renal replacement therapy with regional citrate antigoagulation

From: Total-to-ionized calcium ratio predicts mortality in continuous renal replacement therapy with citrate anticoagulation in critically ill patients

Characteristic or therapy

Ratio of total to ionized Ca2+

ANOVA

 

<2.0

2.0-2.39

≥2.4

or χ2 test

Number

65

90

53

-

Age, years

62.6 ± 1.9

66.6 ± 1.5

62.8 ± 1.8

0.159

Females/males, number

25/40

38/52

27/26

0.382

Reasons for critical illness and MODS, number (percentage)

   Hemorrhagic shock

4 (6.2)

3 (3.3)

2 (3.8)

0.778

   Septic-toxic shock

42 (61.6)

64 (71.1)

38 (71.7)

0.951

   Cardiogenic shock

19 (29.2)

23 (25.6)

13 (24.5)

0.396

History of liver disease, number (percentage)

   Child B-C liver cirrhosis

5 (7.7)

6 (6.7)

13 (24.5)

0.003

History of kidney disease, number

   K/DOQI 0-I

51

67

47

0.331

   K/DOQI II

2

8

1

0.123

   K/DOQI III

2

2

0

0.463

   K/DOQI IV

2

5

1

0.505

   K/DOQI V

8

8

4

0.651

Critical illness score, hemodynamics

   SAPS II, points

46 ± 1.2

47 ± 1.1

49 ± 1.3

0.234

   Heart rate, beats per minute

89 ± 2.4

90 ± 1.8

98 ± 2.7

0.021

   Mean arterial pressure, mm Hg

76.3 ± 1.8

71.8 ± 1.2

68.6 ± 1.3

0.002

Concomitant therapy

Mechanical ventilation, number (percentage)

44 (67.69)

64 (71.11)

40 (75.47)

0.650

   Vasopressors, number (percentage)

44 (67.69)

64 (71.11)

40 (75.47)

0.650

   Norepinephrine dose, µg/kg per minute

0.08 ± 0.05

0.10 ± 0.04

0.12 ± 0.04

<0.001

   Dialysis function

    

Citrate, mmol/L

3.9 ± 0.1

3.9 ± 0.1

3.8 ± 0.2

0.758

   Blood flow, mL/minute

100

100

100

-

   Dialysate flow, mL/hour

2,000

2,000

2,000

-

   Dialysis dose, mL/kg per hour

25 ± 0.2

26 ± 0.2

25 ± 0.2

0.483

   Filter patency, hours

67 ± 0.7

69 ± 0.6

67 ± 0.8

0.136

   CRRT duration, days

19.7 ± 3.4

11.4 ± 1.4

8.6 ± 0.9

0.002

Reasons for CRRT termination, number (percentage)

    

   Restoration of renal function

62 (95.4)

55 (61.1)

0 (0)

<0.001

   Death of patient

3 (4.6)

35 (38.9)

53 (100)

<0.001

Mortality, number (percentage)

    

   28-day mortality

3 (4.6)

35 (38.9)

53 (100)

<0.001

   Hospital mortality

18 (27.7)

41 (45. 6)

53 (100)

<0.001

  1. Data are presented as number (percentage) or as mean ± standard error of the mean. Quantitative data were analyzed by analysis of variance (ANOVA). Categorical data were analyzed by chi-squared test. CRRT, continuous renal replacement therapy; K/DOQI, Kidney Disease Outcomes Quality Initiative; MODS, multiple organ dysfunction syndrome; SAPS II, Simplified Acute Physiology Score II.
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Critical Care

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