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Table 3 Total fluid administration in studies of perioperative goal-directed fluid therapy

From: Clinical review: Volume of fluid resuscitation and the incidence of acute kidney injury - a systematic review

   

Total fluid resuscitation during intervention (ml)

 

Study

Year

Intervention duration

GDT

Control

Difference in mean or median fluid resuscitation (ml)

Studies of GDT in surgery

     

Challand and colleagues [25]

2012

Operation

5,278

4,046

1,232

Cecconi and colleagues [24]

2011

Operation + 1 hour

6,032

2,635

3,397

Mayer and colleagues [35]

2010

Operation

4,528

4,494

34

Jhanji and colleagues [31] without dopexamine

2010

8 hours

4,892

4,351

541

Jhanji and colleagues [31] with dopexamine

  

4,868

 

517

Forget and colleagues [28]

2010

Operation

2,394

2,918

-524

Benes and colleagues [21]

2010

Operation

3,746

3,729

17

Harten and colleagues [30]

2008

Operation

3,500

3,000

500

Kapoor and colleagues [32]

2008

Operation + 8 hours

330 a

80 a

250 b

Donati and colleagues [27]

2007

Operation + 24 hours

4,391

4,285

106

Lopes and colleagues [34]

2007

Operation

4,618

1,694

2,924

Chytra and colleagues [26]

2006

8 hours

4,516

3,649

867

Wakeling and colleagues [42]

2006

Operation

5,000

4,500

500

Noblett and colleagues [37]

2006

Operation

3,638

3,834

-196

Pearse and colleagues [38]

2005

8 hours

2,962

2,164

798

McKendry and colleagues [36]

2004

4 hours

2,020

681

1,339

Gan and colleagues [29]

2002

Operation

5,420

4,775

645

Bonazzi and colleagues [23]

2002

Operation to postoperative day 2

11,130

9,130

2,000

Venn and colleagues [41]

2002

Operation

2,655

2,075

580

Lobo and colleagues [33]

2000

24 hours

6,600

7,200

-600

Pölönen and colleagues [39]

2000

8 hours

3,193

2,772

421 b

Wilson and colleagues [43]

1999

Operation + 12 hours

3,200

3,500

-300

Valentine and colleagues [40]

1998

14 hours preoperative + operation

8,650

6,710

1,940

Bender and colleagues [20]

1997

Operation + 16 hours

5,137

3,789

1,348

Bishop and colleagues [22]

1995

Preoperative and intraoperative

21,975 c

10,876 c

11,099

Studies using GDT in surgery comparing restrictive vs. conservative maintenance fluid

Lobo and colleagues [46]

2011

Operation + 8 hours

3,517

5,250

-1,733

Futier and colleagues [44]

2011

Operation

3,380

5,588

-2,208

Jammer and colleagues [45]

2010

Operation

3,869

6,491

-2,622

  1. Approximate mean or median fluid volume per patient was approximated from data provided in individual studies (see Addition File 1 for further information). Any statistically significantly greater administration of a component of fluid resuscitation in goal-directed therapy (GDT) over the control group is highlighted in bold. aExtra volume above maintenance fluids 500 ml/m2/day documented. bStatistically significant greater fluid administration in GDT deemed clinically insignificant (difference <500 ml). cCumulative fluid balance in study through to end of surgery.