Early course of microcirculatory perfusion in eye and digestive tract during hypodynamic sepsis

Pranskunas, Andrius; Pilvinis, Vidas; Dambrauskas, Zilvinas; Rasimaviciute, Renata; Planciuniene, Rita; Dobozinskas, Paulius; Veikutis, Vincentas; Vaitkaitis, Dinas; Boerma, E Christiaan

doi:10.1186/cc11341

Critical Care

Table 3 Microcirculatory variables over time in septic (n = 9) and sham (n = 4) animals

From: Early course of microcirculatory perfusion in eye and digestive tract during hypodynamic sepsis

	Group	Baseline	3 hours	5 hours	ANOVA (P)
Sublingual mucosa
MFI s	Sepsis	2.73 ± 0.24	1.56 ± 0.30^a	1.54 ± 0.34^a	0.001
	Sham	2.89 ± 0.19	3.00 ± 0.00	3.00 ± 0.00	0.368
MFI l	Sepsis	3.00 ± 0.00	2.94 ± 0.19	3.00 ± 0.00	0.368
	Sham	3.00 ± 0.00	3.00 ± 0.00	3.00 ± 0.00	0.999
PPV s, %	Sepsis	91.4 ± 3.3	71.0 ± 8.1^a	70.2 ± 8.4^a	0.011
	Sham	95.0 ± 0.3	93.8 ± 1.9	94.3 ± 2.0	0.264
PVD s, 1/mm	Sepsis	14.5 ± 3.2	11.6 ± 2.7	12.4 ± 1.9	0.197
	Sham	15.3 ± 1.8	15.4 ± 2.3	16.5 ± 2.0	0.100
TVD s, mm/mm²	Sepsis	27.9 ± 2.4	27.8 ± 2.8	30.0 ± 3.6	0.197
	Sham	29.9 ± 3.9	30.7 ± 2.8	32.6 ± 5.0	0.529
TVD l, mm/mm²	Sepsis	6.0 ± 1.3	7.1 ± 1.1	7.3 ± 2.0	0.197
	Sham	8.4 ± 1.4	8.2 ± 1.3	8.1 ± 3.3	0.761
Het MFI	Sepsis	0.17 ± 0.14	0.44 ± 0.40	0.37 ± 0.24	0.250
	Sham	0.06 ± 0.11	0.00 ± 0.00	0.00 ± 0.00	0.368
Ocular conjunctiva
MFI s	Sepsis	2.74 ± 0.21	2.14 ± 0.33^a	2.00 ± 0.52^a	0.004
	Sham	2.94 ± 0.10	2.83 ± 0.17	2.83 ± 0.29	0.867
MFI l	Sepsis	3.00 ± 0.00	2.98 ± 0.04	3.00 ± 0.00	0.135
	Sham	2.94 ± 0.10	2.94 ± 0.10	3.00 ± 0.00	0.368
PPV s, %	Sepsis	93.4 ± 3.1	84.4 ± 4.2^a	78.4 ± 8.7^a	0.009
	Sham	95.5 ± 0.3	94.4 ± 1.6	94.5 ± 1.2	0.441
PVD s, 1/mm	Sepsis	15.7 ± 3.0	12.7 ± 1.8^a	11.7 ± 3.6	0.042
	Sham	16.9 ± 3.0	16.3 ± 3.6	15.2 ± 3.8	0.160
TVD s, mm/mm²	Sepsis	29.5 ± 4.8	26.6 ± 3.9	25.9 ± 8.4	0.135
	Sham	29.4 ± 6.3	29.1 ± 6.6	28.1 ± 7.8	0.761
TVD l, mm/mm²	Sepsis	7.9 ± 2.0	7.4 ± 2.3	8.0 ± 1.5	0.846
	Sham	8.6 ± 3.4	6.8 ± 1.8	8.5 ± 4.8	0.529
Het MFI	Sepsis	0.13 ± 0.12	0.38 ± 0.32	0.36 ± 0.31	0.113
	Sham	0.06 ± 0.10	0.09 ± 0.09	0.10 ± 0.17	0.867
Jejunal mucosa
MFI s	Sepsis	2.89 ± 0.13	1.90 ± 0.32^a	2.10 ± 0.43^a	< 0.0001
	Sham	3.00 ± 0.00	2.67 ± 0.14	2.64 ± 0.32	0.124
PPV v, %	Sepsis	95.2 ± 2.8	82.6 ± 6.4^a	84.3 ± 8.8^a	0.022
	Sham	99.2 ± 1.4	92.0 ± 7.1	92.6 ± 1.7	0.368
MFI Het	Sepsis	0.11 ± 0.11	0.37 ± 0.19^a	0.50 ± 0.27^a	< 0.0001
	Sham	0.00 ± 0.00	0.09 ± 0.01	0.10 ± 0.10	0.178
Rectal mucosa
MFI s	Sepsis	2.74 ± 0.15	1.95 ± 0.28^a	1.83 ± 0.19^a	< 0.0001
	Sham	3.00 ± 0.00	2.92 ± 0.12	2.67 ± 0.12	0.156
PPV c	Sepsis	93.0 ± 1.5	78.6 ± 6.9^a	80.6 ± 6.3^a	0.018
	Sham	97.1 ± 1.0	95.4 ± 1.6	93.1 ± 0.4	0.156
Het MFI	Sepsis	0.05 ± 0.08	0.36 ± 0.20^a	0.21 ± 0.14^a	0.015
	Sham	0.00 ± 0.00	0.09 ± 0.12	0.28 ± 0.01	0.156

Het MFI, coefficient of MFI s variation; MFI s, microvascular flow index of small vessels; MFI l, microvascular flow index of large vessels; PPVc, percentage of perfused crypts; PPVs, percentage of perfused small vessels; PPVv, percentage of perfused villi; PVDs, perfused vessel density of small vessels; TVD s, total vessel density of small vessels. Data are expressed as mean ± SD. ^aP < 0.05 versus baseline.

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