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Table 3 Details on fluids dependent on total fluid volume in the first day in the ICU and the first 3 days of shock in consecutive ICU patients with septic shock

From: Higher vs. lower fluid volume for septic shock: clinical characteristics and outcome in unselected patients in a prospective, multicenter cohort

 

Day 1, n= 164

Day 1-3, n= 95

Crystalloids

High fluid volume

(> 4.0 L, n = 82)

Low fluid volume

(< 4.0 L, n = 82)

P value

High fluid volume

(> 7.5 L, n = 47)

Low fluid volume

(< 7.5 L, n = 48)

P value

0.9% NaCl, liters

2.3 (1.0-4.0), n = 60

1.0 (0.6-1.6), n = 28

< 0.0001

3.0 (1.1-6.0), n = 35

1.0 (0.9-2.0), n = 19

< 0.01

Ringer solutions, liters

2.5 (2.0-4.0), n = 49

1.5 (1.0-2.0), n = 31

< 0.0001

3.1 (2.0-5.6), n = 34

2.0 (1.0-3.0), n = 29

< 0.01

Other electrolyte solutions, liters

1.0 (0.5-1.4), n = 32

1.0 (0.6-1.0), n = 22

0.48

1.5 (0.9-1.9), n = 29

1.0 (0.6-1.2), n = 18

0.14

Isotonic glucose, liters

1.0 (0.5-1.0), n = 16

0.5 (0.5-0.5), n = 4

0.02

1.0 (0.6-2.7), n = 14

0.5 (0.1-1.0), n = 3

0.10

Colloids, liters

      

   5% albumin

0.5 (0.4-1.0), n = 22

0.5 (0.3-0.8), n = 26

0.72

0.8 (0.5-1.5), n = 24

0.5 (0.4-1.0), n = 21

0.25

   20% albumin

0.2 (0.1-0.3), n = 23

0.2 (0.2-0.3), n = 21

0.78

0.3 (0.1-0.4), n = 19

0.2 (0.2-0.4), n = 20

0.53

   6% HES 130/0.4

1.0 (0.5-1.5), n = 52

0.5 (0.5-1.0), n = 23

< 0.0001

1.5 (1.0-2.0), n = 35

1.0 (0.5-1.5), n = 14

< 0.0001

   6% dextran 70

1.0 (0.9-1.0), n = 10

0.8 (0.5-1.0), n = 9

0.76

1.0 (0.5-1.2), n = 12

0.6 (0.5-1.0), n = 12

0.90

Blood products, liters

      

   Red blood cells

0.7 (0.5-1.2), n = 48

0.3 (0.2-0.5), n = 22

< 0.0001

1.0 (0.6-1.8), n = 39

0.5 (0.3-0.8), n = 20

< 0.0001

   Fresh frozen plasma

0.6 (0.4-1.3), n = 38

0.5 (0.5-0.6), n = 13

< 0.0001

1.4 (0.9-1.8), n = 33

1.1 (0.5-1.1), n = 17

< 0.0001

   Platelet concentrate

0.7 (0.4-1.3), n = 17

0.7 (0.4-1.1), n = 7

0.03

0.7 (0.6-1.4), n = 20

1.2 (0.7-1.6), n = 8

0.02a

  1. Values are presented as median (interquartile range) of the number given in the specific cell; this number denotes the number of patients given the specific solution. Group comparisons were done by Mann-Whitney U test including all patients in the groups (82 versus 82 and 47 versus 48 patients). aThe higher-volume group received significantly more platelets (P = 0.02) because more patients received platelets compared with the lower-volume group (20 versus 8 patients). HES, hydroxyethyl starch (molecular weight/substitution degree).