Figure 2
From: Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs
Major metabolic changes during metformin or lactic acid infusion. Ten pigs were infused with metformin (black bars) and five pigs with lactic acid (white dotted bars). Infusion of metformin started after baseline recordings (time 0) and lasted 2.5 to 5 hours (dose infused ranged between 4 and 8 g). Infusion of lactic acid started after baseline recordings (time 0) and continued until end of the study, with velocity adjusted to mimic the rise of lactatemia of metformin-intoxicated pigs. Arterial pH (A), lactatemia (B), glycemia (C), global oxygen (O2) delivery (D), consumption (E) and extraction (F) were recorded every hour. Data are reported as mean and SD. *P < 0.05 vs. time 0 within group. To convert glucose in mmol/L, divide by 18.