Marker | Study | Assay†| Optimal Timing | Cut-off Point (pg/ml) | Sensitivity/Specificity | AUC¶ | Proportion of Elevated BNPs (%) |
---|---|---|---|---|---|---|---|
NT-proBNP | Varpula 2007 [28] | Roche, Elecsys 2010 analyzer | On admission | 7090 | 58/66 | 0.631 | 40.6 |
 | Mokart 2007 [29] | Roche, Elecsys 2010 analyzer | Day 2 after admission | 6624 | 86/77 | 0.87 | 54.9 |
 | Roch 2005 [31] | Roche, Elecsys 2010 analyzer | Within 24 hours after admission | 13600 | 73/83 | 0.8 | 48.7 |
 | Brueckmann 2005 [32] | Enzyme immunoassay (Biozol) | Day 2 after admission | 11900 | 50/90 | 0.68 | 21.1 |
 | Sturgess 2010b* [23] | Roche, Elecsys 2010 analyzer | Within 72 hours after admission | 400 | 83/40 | 0.67 | 66.7 |
BNP | Perman 2011 [22] | Biosite Diagnostics, Triage | On admission | 49 | 63/69 | 0.69 | 47.6 |
 | Zhao 2009 [24] | Immunofluorescence assay‡ | 24 hours after admission | 681.4 | 91.4/80.3 | 0.915 | 47.1 |
 | Chen 2009 [25] | Biosite Diagnostics, Triage | Within 24 hours after admission | 113 | 86/55 | 0.737 | 32.1 |
 | Yucel 2008 [26] | Immunoradiometric assay, Shionoria | On admission | 32.1 | 100/95 | 0.99 | 52.5 |
 | Post 2008 [27] | Biosite Diagnostics, Triage | Day 5 after admission | 121 | 76.3/52.7 | 0.648 | 59.1 |
 | Ueda 2006 [30] | Immunoradiometric assay, Shionoria | Day 2 after admission | 650 | 92/80 | 0.85 | 59.1 |
 | Charpentier 2004 [33] | Immunoradiometric assay, Shionoria | Day 2 after admission | 190 | 70/67 | 0.66 | 44.1 |
 | Sturgess 2010a* [23] | Biosite Diagnostics, Triage | Within 72 hours after admission | 254 | 83/60 | 0.76 | 52.4 |