Table 1 Characteristics of included studies
Marker | Study | Country | Setting | Population | NO. | Male (%) | Age (year) | Outcome | Mortality (%) |
|---|---|---|---|---|---|---|---|---|---|
NT-proBNP | Varpula 2007 [28] | Finland | 24 ICUs | Severe sepsis or septic shock | 254 | 69 | 59 ± 15 | In-hospital mortality | 26 |
|  | Mokart 2007 [29] | France | ICU | Cancer patients developing septic shock | 51 | 63 | 56 (50 - 68)†| ICU mortality | 51 |
|  | Roch 2005 [31] | France | General ICU | Septic shock | 39 | 82.1 | 63 ± 12 | ICU mortality | 56 |
|  | Brueckmann 2005 [32] | Germany | Three departments in one hospital‡ | Severe sepsis | 57 | 74 | 55.0 ± 16.3 | 28-day mortality | 28 |
|  | Sturgess 2010b* [23] | Australia | ICU | Septic shock | 21 | 61.9 | 65 ± 17 | In-hospital mortality | 29 |
BNP | Perman 2011 [22] | USA | Emergency departments of 10 centers | Clinical evidence of sepsis | 825 | 49 | 53.5 ± 19.6 | A composite of events § | 6.6 |
|  | Zhao 2009 [24] | China | Surgical ICU | Severe sepsis or septic shock | 102 | 53.9 | ─ | 28-day mortality | 38.2 |
|  | Chen 2009 [25] | China | Emergency department | Sepsis | 327 | 60.6 | 69.5 ± 13.4 | 28-day mortality | 37.3 |
|  | Yucel 2008 [26] | Turkey | General ICU | Sepsis | 40 | ─ | ─ | 28-day mortality | 50 |
|  | Post 2008 [27] | Germany | ICU | Septic shock | 93 | 55 | 65(53 - 73.5)†| 30-day mortality | 40.9 |
|  | Ueda 2006 [30] | Japan | Department of Emergency and Critical Care Medicine | Septic shock | 22 | 77.3 | 62.5 ± 19.3 | 28-day mortality | 54.5 |
|  | Charpentier 2004 [33] | France | Medical ICU | Severe sepsis or septic shock | 34 | 47.1 | 56 ± 15.7 | 28-day mortality | 29 |
|  | Sturgess 2010a* [23] | Australia | ICU | Septic shock | 21 | 61.9 | 65 ± 17 | In-hospital mortality | 29 |