The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs

Pape, Andreas; Kutschker, Saskia; Kertscho, Harry; Stein, Peter; Horn, Oliver; Lossen, Mischa; Zwissler, Bernhard; Habler, Oliver

doi:10.1186/cc11324

Critical Care

Table 3 Oxygen-derived parameters investigated at baseline and after hemodilution to the individual Hb_crit of the RL-, HS-, GEL- and TS-groups.

From: The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs

Parameter	Group	Baseline	Hb_crit RS-group		Hb_crit HS-group		Hb_crit GEL-group		Hb_crit TS-group
Hb	TS	7.6 ± 0.6	3.7 ± 0.2	+	3.0 ± 0.1	+	2.7 ± 0.1	+	2.1 ± 0.4	+
(g/dL)	GEL	7.7 ± 0.5	3.6 ± 0.3	+	2.9 ± 0.2	+	2.7 ± 0.7	+	n.a.
	HS	7.6 ± 0.4	3.7 ± 0.3	+	3.0 ± 0.6	+	n.a.		n.a.
	RS	7.9 ± 0.5	3.7 ± 0.6	+	n.a.		n.a.		n.a.
Temp.	TS	37.8 ± 1.3	37.5 ± 0.5		37.6 ± 0.4		37.7 ± 1.2		37.6 ± 1.2
(°C)	GEL	37.5 ± 1.0	37.4 ± 1.2		37.3 ± 0.8		37.2 ± 1.0		n.a.
	HS	37.6 ± 1.1	37.6 ± 1.0		37.4 ± 1.2		n.a.		n.a.
	RS	37.7 ± 0.7	37.4 ± 0.6		n.a.		n.a.		n.a.
paO₂	TS	94 ± 9	95 ± 12	§	100 ± 13		98 ± 14		105 ± 22
(mmHg)	GEL	98 ± 10	99 ± 19	§	101 ± 14		95 ± 18		n.a.
	HS	95 ± 7	98 ± 9	§	101 ± 11		n.a.		n.a.
	RS	100 ± 8	79 ± 10	+	n.a.		n.a.		n.a.
paCO₂	TS	34 ± 3	35 ± 4		34 ± 4		34 ± 4		33 ± 4
(mmHg)	GEL	34 ± 2	35 ± 3		34 ± 4		35 ± 4		n.a.
	HS	33 ± 4	33 ± 3		33 ± 3		n.a.		n.a.
	RS	32 ± 3	32 ± 4		n.a.		n.a.		n.a.
pvO₂	TS	34 ± 3	31 ± 5		32 ± 4		31 ± 4		29 ± 4	+
(mmHg)	GEL	34 ± 2	32 ± 3		34 ± 2	#	32 ± 4		n.a.
	HS	33 ± 4	35 ± 4		29 ± 3	+	n.a.		n.a.
	RS	32 ± 3	34 ± 3		n.a.		n.a.		n.a.
DO₂I	TS	428 ± 45	367 ± 58	+	324 ± 54	+	287 ± 20	+	253 ± 84	+
(mL/min/m²)	GEL	478 ± 67	348 ± 51	+	328 ± 35	+	289 ± 44	+	n.a.
	HS	455 ± 53	353 ± 22	+	303 ± 65	+	n.a.		n.a.
	RS	487 ± 109	339 ± 69	+	n.a.		n.a.		n.a.
VO₂I	TS	223 ± 33	219 ± 29		203 ± 14		216 ± 34		199 ± 35
(mL/min/m²)	GEL	219 ± 17	210 ± 10		201 ± 12		199 ± 12		n.a.
	HS	229 ± 37	199 ± 10		211 ± 35		n.a.		n.a.
	RS	222 ± 23	203 ± 26		n.a.		n.a.		n.a.
O₂-ER	TS	37 ± 5	46 ± 11		45 ± 7	#	46 ± 11		52 ± 13	+
(%)	GEL	35 ± 5	46 ± 8		41 ± 7	#	45 ± 12	+	n.a.
	HS	38 ± 9	44 ± 6		52 ± 9	+	n.a.		n.a.
	RS	39 ± 7	44 ± 6		n.a.		n.a.		n.a.
pH	TS	7.57 ± 0.04	7.53 ± 0.04		7.52 ± 0.04		7.51 ± 0.04		7.50 ± 0.06
	GEL	7.58 ± 0.02	7.50 ± 0.03	+	7.49 ± 0.03		7.47 ± 0.04		n.a.
	HS	7.59 ± 0.04	7.55 ± 0.05	+	7.53 ± 0.04		n.a.		n.a.
	RS	7.58 ± 0.05	7.42 ± 0.08	+	n.a.		n.a.		n.a.
BE	TS	8.7 ± 3.4	6.1 ± 3.5	§	5.0 ± 3.4		4.2 ± 3.4	+	2.4 ± 4.0	+
(mmol/L)	GEL	9.4 ± 2.0	4.0 ± 1.7	+§	2.7 ± 2.1	+	1.8 ± 2.8	+	n.a.
	HS	9.3 ± 2.4	6.2 ± 3.0	+§	4.6 ± 2.5	+	n.a.		n.a.
	RS	7.5 ± 2.1	-3.5 ± 3.4	+	n.a.		n.a.		n.a.
Lactate	TS	1.9 ± 0.9	1.7 ± 0.8		1.7 ± 0.8		1.7 ± 0.9		2.3 ± 1.0
(mmol/L)	GEL	1.4 ± 0.3	1.2 ± 0.3		1.1 ± 0.3		1.1 ± 0.3		n.a.
	HS	1.7 ± 0.7	1.6 ± 0.5		1.8 ± 0.1		n.a.		n.a.
	RS	1.4 ± 0.6	1.3 ± 0.6		n.a.		n.a.		n.a.

Temp, body core temperature; Hb, haemoglobin concentration; paO₂, arterial O₂ partial pressure; pvO₂, mixed venous O₂ partial pressure; paCO₂, arterial CO₂ partial pressure; VO₂I and DO₂I, indices of O₂ consumption and delivery; O₂-ER, O₂ extraction ratio; pH, pH value; BE, base excess; lactate, lactate concentration; n.a., not applicable. *P < 0.05 vs. gelatin, #P < 0.05 vs. HS, §P < 0.05 vs. RS, +P < 0.05 vs. baseline.

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